Endonuclease/Exonuclease/phosphatase family

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Endonuclease/Exonuclease/phosphatase family
Endonuclease/Exonuclease/phosphatase family
	Structure of the multifunctional DNA-repair enzyme exonuclease III.
Identifiers
Symbol	Exo_endo_phos
Pfam	PF03372
InterPro	IPR005135
PROSITE	PDOC00598
SCOP2	1ako / SCOPe / SUPFAM
OPM superfamily	139
OPM protein	1zwx
CDD	cd08372
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.^[2]

Examples[]

AP endonuclease proteins EC 4.2.99.18,
DNase I proteins EC 3.1.21.1,
Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
Sphingomyelinase EC 3.1.4.12
Nocturnin, an NADPH 2' phosphatase^[3]

Subfamilies[]

Inositol polyphosphate related phosphatase InterPro: IPR000300

Human proteins containing this domain[]

; ; ; ; APEX1; ; ; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; ; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP; Nocturnin;

Notes[]

^ Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.
^ Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
^ Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A (May 2019). "The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)". Nature Communications. 10 (1): 2367. doi:10.1038/s41467-019-10125-z. PMC 6542800. PMID 31147539. Lay summary – Science Daily. {{cite journal}}: Cite uses deprecated parameter |lay-url= (help)

References[]

Dlakić M (June 2000). "Functionally unrelated signalling proteins contain a fold similar to Mg²⁺-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–3. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.
Lahm A, Suck D (December 1991). "DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex". J. Mol. Biol. 222 (3): 645–67. doi:10.1016/0022-2836(91)90502-W. PMID 1748997.

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[pmid7885481-1] Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.

[PUB00007746-2] Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.

[Estrella_2019b-3] Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A (May 2019). "The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)". Nature Communications. 10 (1): 2367. doi:10.1038/s41467-019-10125-z. PMC 6542800. PMID 31147539. Lay summary – Science Daily. {{cite journal}}: Cite uses deprecated parameter |lay-url= (help)

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[2]

[3]

v t Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)