Diacylglycerol lipase
| diacylglycerol lipase, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | DAGLA | ||||||
| Alt. symbols | C11orf11 | ||||||
| NCBI gene | 747 | ||||||
| HGNC | 1165 | ||||||
| RefSeq | NM_006133 | ||||||
| UniProt | Q9Y4D2 | ||||||
| Other data | |||||||
| EC number | 3.1.1.- | ||||||
| Locus | Chr. 11 q12.3 | ||||||
| |||||||
| diacylglycerol lipase, beta | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | DAGLB | ||||||
| NCBI gene | 221955 | ||||||
| HGNC | 28923 | ||||||
| RefSeq | NM_139179 | ||||||
| UniProt | Q8NCG7 | ||||||
| Other data | |||||||
| EC number | 3.1.1.- | ||||||
| Locus | Chr. 7 p22.1 | ||||||
| |||||||
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
Inhibitors[]
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
References[]
- ^ Bisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631. PMID 14610053.
External links[]
- Diacylglycerol+Lipase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.34
Categories:
- Genes on human chromosome 11
- Genes on human chromosome 7
- EC 3.1