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FG-7142
Names
Preferred IUPAC name
N -Methyl-5H -pyrido[3,4-b ]indole-2-carboxamide
Other names
ZK-31906
Identifiers
3D model (JSmol )
ChemSpider
MeSH
C526324
UNII
InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
N Key: QMCOPDWHWYSJSA-UHFFFAOYSA-N
N
CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
Properties
C13 H11 N3 O
Molar mass
225.24594
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N what is Y N
Infobox references
Chemical compound
FG-7142 (ZK-31906 ) is a drug which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor .[1] anorectic ,[2] anxiogenic and pro-convulsant effects.[3] acetylcholine and noradrenaline ,[4] [5]
References [ ]
^ Stevenson CW, Halliday DM, Marsden CA, Mason R (2007). "Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions". Synapse . 61 (8): 646–63. CiteSeerX 10.1.1.323.5370 doi :10.1002/syn.20414 . PMID 17503486 . S2CID 13415418 . ^ Cottone P, Sabino V, Steardo L, Zorrilla EP (May 2007). "FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability" . Neuropsychopharmacology . 32 (5): 1069–81. doi :10.1038/sj.npp.1301229 PMID 17077811 . ^ Evans AK, Lowry CA (Winter 2007). "Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor: neurochemical, neurophysiological, and behavioral effects" . CNS Drug Reviews . 13 (4): 475–501. doi :10.1111/j.1527-3458.2007.00025.x PMC 6494137 PMID 18078430 . ^ Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R (2006). "Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat". Neuroscience . 141 (3): 1481–8. doi :10.1016/j.neuroscience.2006.05.006 . PMID 16781820 . S2CID 24944657 . ^ McNally GP, Augustyn KA, Richardson R (2008). "GABAA receptors determine the temporal dynamics of memory retention" . Learning and Memory . 15 (3): 106–11. doi :10.1101/lm.806008 PMC 2275652 PMID 18285469 .
Ionotropic
GABAA
Positive modulators (abridged; see here for a full list): Alcohols (e.g., drinking alcohol , 2M2B )Anabolic steroids Avermectins (e.g., ivermectin )Barbiturates (e.g., phenobarbital )Benzodiazepines (e.g., diazepam )Bromide compounds (e.g., potassium bromide )Carbamates (e.g., meprobamate )Carbamazepine Chloralose Chlormezanone Clomethiazole Dihydroergolines (e.g., ergoloid (dihydroergotoxine) )Etazepine Etifoxine Fenamates (e.g., mefenamic acid )Flavonoids (e.g., apigenin , hispidulin )Fluoxetine Flupirtine Imidazoles (e.g., etomidate )Kava constituents (e.g., kavain )Lanthanum Loreclezole Monastrol Neuroactive steroids (e.g., allopregnanolone , cholesterol , THDOC )Niacin Niacinamide Nonbenzodiazepines (e.g., β-carbolines (e.g., abecarnil ), cyclopyrrolones (e.g., zopiclone ), imidazopyridines (e.g., zolpidem ), pyrazolopyrimidines (e.g., zaleplon ))Norfluoxetine Petrichloral Phenols (e.g., propofol )Phenytoin Piperidinediones (e.g., glutethimide )Propanidid Pyrazolopyridines (e.g., etazolate )Quinazolinones (e.g., methaqualone )Retigabine (ezogabine) ROD-188 Skullcap constituents (e.g., baicalin )Stiripentol (e.g., sulfonmethane (sulfonal) )
Topiramate Valerian constituents (e.g., valerenic acid )Volatiles /gases (e.g., chloral hydrate , chloroform , diethyl ether , paraldehyde , sevoflurane )Negative modulators: 11-Ketoprogesterone 17-Phenylandrostenol α5IA (LS-193,268) Anabolic steroids Amiloride Anisatin β-Lactams (e.g., penicillins , cephalosporins , carbapenems )Basmisanil Bemegride Bicyclic phosphates (TBPS , TBPO , IPTBO )BIDN Bilobalide Bupropion Chlorophenylsilatrane Cicutoxin Cloflubicyne Cyclothiazide DHEA DHEA-S Dieldrin DMCM EBOB FG-7142 (ZK-31906) (e.g., fipronil )
Flavonoids (e.g., amentoflavone , oroxylin A )Flumazenil Fluoroquinolones (e.g., ciprofloxacin )Flurothyl Furosemide Golexanolone Iomazenil (123 I) IPTBO Isopregnanolone (sepranolone) L-655,708 Laudanosine Lindane Morphine Morphine-3-glucuronide MRK-016 Naloxone Naltrexone Nicardipine Nonsteroidal antiandrogens (e.g., apalutamide , bicalutamide , enzalutamide , flutamide , nilutamide )Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane Picrotoxin (i.e., picrotin , picrotoxinin and dihydropicrotoxinin )Pregnenolone sulfate PWZ-029 Radequinil Ro 15-4513 Sarmazenil Suritozole TB-21007 TBPS Terbequinil TETS Thujone Zinc ZK-93426 GABAA -ρ
Metabotropic
See also
Receptor/signaling modulators GABAA receptor positive modulators GABA metabolism/transport modulators
GABA receptor antagonists GABA synthesis inhibitors Glycine receptor antagonists Glutamate receptor agonists Other
Categories :
Anxiogenics Beta-Carbolines Carboxamides Convulsants GABAA receptor negative allosteric modulators Nootropics Biochemistry stubs Hidden categories:
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