List of opioids

Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives[]

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products[]

Polish heroin (Compote, Kompot)
Diascordium
B&O Supprettes
Dover's powder
Kendal Black Drop
Laudanum
Mithridate
Opium
Paregoric
Poppy straw concentrate
Poppy tea
Smoking opium
Theriac

Natural opiates[]

Opium alkaloids[]

Codeine
Morphine
Oripavine
Pseudomorphine
Thebaine

Structures

Morphides
Codeine	Morphine	Oripavine	Pseudomorphine	Thebaine

Alkaloid salts mixtures[]

Pantopon
Papaveretum (Omnopon)

Semisynthetics including Bentley compounds[]

Morphine family[]

^[1]
2,4-Dinitrophenylmorphine
^[2]
6-Methylenedihydrodesoxymorphine
^[3]
Azidomorphine
Chlornaltrexamine
Chloroxymorphamine ^[4]
Desomorphine (dihydrodesoxymorphine)
Dihydromorphine
^[5]^{[full citation needed]}
Hydromorphinol
Methyldesorphine
Morphine methylbromide
N-Phenethylnordesomorphine
N-Phenethyl-14-ethoxymetopon
N-Phenethylnormorphine
(metabolite of nicodicodeine)
RAM-378

Structures of Morphine family

Morphine family
	2,4-Dinitrophenylmorphine		6-Methylenedihydrodesoxymorphine
Azidomorphine	Chlornaltrexamine	Chloroxymorphamine	Desomorphine (Dihydrodesoxymorphine)	Dihydromorphine
	Hydromorphinol	Methyldesorphine	N-Phenethylnormorphine
RAM-378

3,6-diesters of morphine[]

Acetylpropionylmorphine
Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
Dibutyrylmorphine [1]
Dibenzoylmorphine (first designer drug)
Dipropanoylmorphine
Heroin (diacetylmorphine)
Nicomorphine

Structures

3,6-diesters of morphine
Acetylpropionylmorphine		Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
Dibutyrylmorphine	Dibenzoylmorphine
Dipropanoylmorphine	Heroin (diacetylmorphine)	Nicomorphine

Codeine-dionine family[]

6-Monoacetylcodeine
Benzylmorphine
Codeine methylbromide
Desocodeine [2]^{[permanent dead link]}
(6-O-Methylcodeine) [3]
[4]^{[permanent dead link]}
Methyldihydromorphine (dihydroheterocodeine)
Ethylmorphine (dionine)
Heterocodeine
Isocodeine [5]
Pholcodine (morpholinylethylmorphine)
Myrophine
Thebacon
[6]

Structures

Codeine-dionine family
6-Monoacetylcodeine	Benzylmorphine	Codeine methylbromide	Desocodeine
	Methyldihydromorphine (dihydroheterocodeine)	Ethylmorphine	Heterocodeine	Isocodeine
Pholcodine	Myrophine

Morphinones and morphols[]

14-Cinnamoyloxycodeinone
14-Ethoxymetopon
14-Methoxymetopon
14-Phenylpropoxymetopon
3-Acetyloxymorphone
3,14-Diacetyloxymorphone
7-Spiroindanyloxymorphone
[7]
[8]
Acetylmorphone
α-hydrocodol (=dihydrocodeine, )
Benzhydrocodone
cas?
Codeinone
Codoxime
Conorfone (codorphone)
IBNtxA
Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
Hydrocodone
Hydromorphone
[9]
Metopon (=methyldihydromorphinone)
[10]
Morphinone
[11]
N-Phenethyl-14-ethoxymetopon
Noroxymorphone
Oxycodone
Oxymorphol
Oxymorphone
Pentamorphone
Semorphone

Structures

Morphinones and morphols
14-Cinnamoyloxycodeinone	14-Ethoxymetopon	14-Methoxymetopon	14-Phenylpropoxymetopon	7-Spiroindanyloxymorphone
		Acetylmorphone	α-hydrocodol (Dihydrocodeine)
Codeinone	Codorphone	Codol (Codeine Phosphate)	Codoxime	IBNtxA
Thebacon	Hydrocodone	Hydromorphone		Metopon (methyldihydromorphinone)
	Morphinone		N-Phenethyl-14-ethoxymetopon	Oxycodone
Oxymorphol	Oxymorphone	Pentamorphone	Semorphone

Morphides[]

α-Chlorocodide (= chlorocodide) [12]
[13]
(= chloromorphide)
[14]
[15]
Chlorodihydrocodide [16]
Chloromorphide
[17]

Structures

Morphides

	Chloromorphide

Dihydrocodeine series[]

14-Hydroxydihydrocodeine
Acetyldihydrocodeine
Dihydrocodeine
Dihydrodesoxycodeine (desocodeine)
Dihydroisocodeine
Nicocodeine
Nicodicodeine

Structures

Morphides
14-Hydroxydihydrocodeine	Acetyldihydrocodeine	Dihydrocodeine	Dihydrodesoxycodeine
Dihydroisocodeine	Nicocodeine	Nicodicodeine

Nitrogen morphine derivatives[]

cas? [18]
Codeine-N-oxide [19]
Morphine-N-oxide

Structures

Morphides
	Codeine-N-oxide	Morphine-N-oxide

Hydrazones[]

Oxymorphazone

Structures

Hydrazones
Oxymorphazone

Halogenated morphine derivatives[]

1-Iodomorphine

Structures

Other open chain opioids
		1-Iodomorphine

Active opiate metabolites[]

Codeine-6-glucuronide
Codeine-N-oxide (genocodeine)[20]
[21]
Morphine-6-glucuronide
3-Monoacetylmorphine
6-Monoacetylmorphine
Morphine-N-oxide (genomorphine)
Naltrexol [22]
Norcodeine
Normorphine

Structures

Active opiate metabolites
Codeine-N-oxide		Morphine-6-glucuronide	6-Monoacetylmorphine
Morphine-N-oxide	Naltrexol	Norcodeine	Normorphine

Morphinans[]

Levomethorphan

Morphinan series[]

3-Hydroxymorphinan
[23]
Cyclorphan
[24]
Levorphanol
Levophenacylmorphan
Levomethorphan
Methorphan (racemethorphan)
Morphanol (racemorphanol)
Norlevorphanol
[25]
Oxilorphan
Phenomorphan
Proxorphan
Ro4-1539
[26]^{[permanent dead link]}Xorphanol

Structures

Other morphinans
	Cyclorphan	Dextrallorphan		Levophenacylmorphan
Levomethorphan	Norlevorphanol		Oxilorphan	Phenomorphan
Dextromethorphan levomethorphan	Morphanol	Ro4-1539		Xorphanol

Others[]

*
Aknadinine
Butorphanol
Cyprodime
Drotebanol
Ketorfanol
Nalbuphine

Structures

Other Morphinans
				Aknadinine
Butorphanol			Cyprodime	Drotebanol
	Nalbuphine	Sinococuline	Sinomenine

Benzomorphans[]

(5,9-DEHB) [27]
8-Carboxamidocyclazocine (8-CAC)
Alazocine
Anazocine [28]
Bremazocine
Butinazocine [29]
Carbazocine [30]
Cogazocine
Cyclazocine
Dezocine
Eptazocine
Etazocine [31]^{[permanent dead link]}
Ethylketazocine [32]
Fedotozine [33]
Fluorophen [34]
Gemazocine [35]^{[permanent dead link]}
Ibazocine [36]^{[permanent dead link]}
Ketazocine
Metazocine
Moxazocine [37]
Pentazocine
Phenazocine
Quadazocine [38]
SKF-10047
[39]
Tonazocine
Volazocine
Zenazocine [40]

Structures

Benzomorphans
	8-Carboxamidocyclazocine	Alazocine	Anazocine	Bremazocine
Butinazocine	Carbazocine	Cogazocine	Cyclazocine	Dezocine
Eptazocine	Etazocine	Ethylketocyclazocine	Fedotozine	Fluorophen
Gemazocine	Ibazocine	Ketazocine	Metazocine	Moxazocine
Pentazocine	Phenazocine	Quadazocine		Tonazocine
Volazocine	Zenazocine

4-Phenylpiperidines[]

Pethidine

Pethidines (meperidines)[]

4-Fluoropethidine
Allylnorpethidine
Anileridine
Benzethidine
Carperidine
Difenoxin
Diphenoxylate
Etoxeridine (carbetidine)
Furethidine
Hydroxypethidine (bemidone)
Morpheridine
Oxpheneridine (carbamethidine)
Pethidine (meperidine)
Pethidine intermediate A
Pethidine intermediate B (norpethidine)
Pethidine intermediate C (pethidinic acid)
Pheneridine
Phenoperidine
Piminodine
Properidine (ipropethidine)
Sameridine

Structures

Pethidines (meperidines)
4-Fluoropethidine	8-Carboxamidocyclazocine	Allylnorpethidine	Anileridine	Benzethidine
Carperidine	Difenoxin	Diphenoxylate	Etoxeridine	Furethidine
Hydroxypethidine	Morpheridine		Oxpheneridine	Pethidine
Pethidine intermediate A	Pethidine intermediate B	Pethidine intermediate C	Pheneridine	Phenoperidine
Piminodine	Properidine	Sameridine

Prodines[]

Allylprodine
(α/β)-Meprodine
Desmethylprodine (MPPP)
PEPAP
(α/β)-Prodine
Prosidol
Trimeperidine (promedol)

Structures

Prodines
Allylprodine	(α/β)-Meprodine	Desmethylprodine (MPPP)	PEPAP	Prodine
Prosidol	Prosidol

Ketobemidones[]

Structures

Ketobemidones
Acetoxyketobemidone	Droxypropine	Ketobemidone	Methylketobemidone	Propylketobemidone

Others[]

Alvimopan
Loperamide
LS-115509
Picenadol

Structures

Other phenylpiperidines
Alvimopan	Loperamide	LS-115509	Picenadol

Open chain opioids[]

Methadone

Amidones[]

Dextromethadone [41]
Dipipanone
Isomethadone [42]
Levomethadone
Methadone
Methadone intermediate [43]
Normethadone
Norpipanone [44]
Phenadoxone (heptazone)

Structures

Amidones
Dextromethadone	Dipipanone	Isomethadone
	Levomethadone	Methadone	Methadone intermediate
Normethadone	Norpipanone	Phenadoxone	Pipidone

Methadols[]

Acetylmethadol
Alphaacetylmethadol
Alphamethadol
Betacetylmethadol
Betamethadol
Dimepheptanol (racemethadol)
Isomethadol
Levacetylmethadol
Noracymethadol

Structures

Other open chain opioids
Alphaacetylmethadol	Dimepheptanol	Levacetylmethadol

Moramides[]

Structures

Other open chain opioids
Desmethylmoramide	Dextromoramide	Levomoramide	Moramide intermediate	Racemoramide

Thiambutenes[]

Structures

Thiambutenes
Diethylthiambutene	Dimethylthiambutene	Ethylmethylthiambutene
Piperidylthiambutene	Thiambutene	Tipepidine

Phenalkoxams[]

Dextropropoxyphene (propoxyphene)
Dimenoxadol
Dioxaphetyl butyrate
Levopropoxyphene
Norpropoxyphene

Structures

Phenalkoxams
Dextropropoxyphene (propoxyphene)	Dimenoxadol	Dioxaphetyl butyrate	Levopropoxyphene	Norpropoxyphene

Ampromides[]

Structures

Ampromides
Diampromide	Phenampromide	Propiram

Others[]

Embutramide
IC-26
Isoaminile
Lefetamine
R-4066

Structures

Other open chain opioids
Embutramide	IC-26	Isoaminile	Lefetamine	R-4066

Anilidopiperidines[]

Fentanyl

3-Allylfentanyl
3-Methylfentanyl
3-Methylthiofentanyl
4-Phenylfentanyl
Alfentanil
α-Methylacetylfentanyl
α-Methylfentanyl
Benzylfentanyl [46]
β-hydroxythiofentanyl
β-Methylfentanyl
Brifentanil
Butyrfentanyl
Carfentanil
Fentanyl
Lofentanil
N-Methylcarfentanil
Mirfentanil
Ocfentanil
Ohmefentanyl
Parafluorofentanyl
Phenaridine
R-30490
Remifentanil
Sufentanil
[47]
Thiofentanyl
Trefentanil

Structures

Anilidopiperidines
3-Allylfentanyl	3-Methylfentanyl	3-Methylthiofentanyl	4-Phenylfentanyl	Alfentanil
Alphamethylacetylfentanyl	Alphamethylfentanyl	Alphamethylthiofentanyl	Benzylfentanyl	Betahydroxyfentanyl
Betahydroxythiofentanyl	Betamethylfentanyl	Brifentanil	Carfentanil	Fentanyl
Lofentanil	Mirfentanil	Ocfentanil	Ohmefentanyl	Parafluorofentanyl
Phenaridine	Remifentanil	Sufentanil		Thiofentanyl
Trefentanil

Oripavine derivatives[]

Thienorphine

7-PET
Acetorphine
Alletorphine (N-allyl-noretorphine)
BU-48
Buprenorphine
Buprenorphine-3-glucuronide
Cyprenorphine
Dihydroetorphine
Etorphine
Homprenorphine
18,19-Dehydrobuprenorphine (HS-599) [48] [49]
[50]
[51] [52]
Norbuprenorphine
Norbuprenorphine-3-glucuronide
Thevinone [53]
Thienorphine [54]

Structures

Oripavine derivatives
7-PET	Acetorphine	Alletorphine	BU-48	Buprenorphine
Cyprenorphine	Dihydroetorphine	Etorphine	Homprenorphine	18,19-Dehydrobuprenorphine
		Norbuprenorphine	Thevinone	Thienorphine

Phenazepanes[]

Ethoheptazine
Meptazinol
Metheptazine
Metethoheptazine
Proheptazine

Structures

Phenazepanes
Ethoheptazine	Meptazinol	Metheptazine	Metethoheptazine	Proheptazine

Pirinitramides[]

Bezitramide
Piritramide

Structures

Pirinitramides
Bezitramide	Piritramide

Benzimidazoles[]

Clonitazene
Etonitazene
Isotonitazene
Metonitazene

Structures

Benzimidazoles
Clonitazene	Etonitazene	Isotonitazene	Metonitazene	Nitazene: R = hydrogen

Indoles[]

18-Methoxycoronaridine
7-Hydroxymitragynine
Akuammine
Coronaridine
Eseroline
Hodgkinsine
Ibogaine
Mitragynine
Mitragynine pseudoindoxyl
Noribogaine
Pericine
Pseudoakuammigine

Structures

Indoles
18-Methoxycoronaridine		7-Hydroxymitragynine		Akuammine
Eseroline	Hodgkinsine	Mitragynine	Pericine	Pseudoakuammigine

Beta-Amino Ketones[]

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one

Structures

	Indoles
3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines[]

Structures

Diphenylmethylpiperazines
BW373U86	DPI-221	DPI-287	DPI-3290	SNC-80

Opioid peptides[]

β-neo-endorphin

Dynorphins[]

Big dynorphin
Dynorphin A
Dynorphin B
Leumorphin

Structures

Dynorphins
Big dynorphin	Dynorphin A	Dynorphin B

Endomorphins[]

Endomorphin-1
Endomorphin-2

Endorphins[]

Structures

Dynorphins
Beta-endorphin	Alpha-endorphin	Gamma-endorphin	α-neo-endorphin	β-neo-endorphin

Enkephalins[]

DADLE
DAMGO
Deltorphin [55]
Met-enkephalin
Leu-enkephalin

Structures

Enkephalins
DADLE	DAMGO	Deltorphin	Met-enkephalin	Leu-enkephalin

Propeptides[]

Proenkephalin
Proendorphin
Proopiomelanocortin

Others / unknown[]

Adrenorphin
Amidorphin
Biphalin
Casokefamide
Casomorphins
Cytochrophin-4
(Tyr-D-Arg-Phe-Lys-NH2)[56] [57]
Deltorphin I
Dermorphin
DPDPE [58]
Frakefamide
Gliadorphin
Gluten exorphins
Hemorphin-4
Metkefamide
Morphiceptin
Nociceptin
Octreotide
Opiorphin
Rubiscolin
Spinorphin
TRIMU 5
Tynorphin
Valorphin
Zyklophin

Structures

Other or unknown opioid peptides
Adrenorphin	Amidorphin	Casomorphin		Deltorphin
Dermorphin	DPDPE	Endomorphin-1 Endomorphin-2	Gliadorphin	Morphiceptin
Nociceptin	Octreotide	Opiorphin	Rubiscolin	TRIMU 5

Others[]

AD-1211
AH-7921
Axomadol
Azaprocin
BDPC
Bisnortilidine [59] [60]
BRL-52537
Bromadol
Bromadoline
Ciprefadol
Ciramadol
Doxpicomine
Enadoline
Faxeladol
GR-89696
Herkinorin
ICI-199,441
ICI-204,448
Ketamine
LPK-26
Lufuradom
Metofoline
MT-45
Desmethylclozapine
Nexeridine
NNC 63-0532
Nortilidine
O-Desmethyltramadol
Phenadone
Phencyclidine
Prodilidine
Profadol
Ro64-6198
Salvinorin A
Salvinorin B ethoxymethyl ether
Salvinorin B methoxymethyl ether
SB-612,111
SC-17599
RWJ-394,674
TAN-67
Tapentadol
Thiobromadol (C-8813)
Tifluadom
Tilidine
Tramadol
Trimebutine
U-47700
U-50,488
U-69,593
Viminol
1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)

Opioid antagonists and inverse agonists[]

4-Caffeoyl-1,5-quinide
5'-Guanidinonaltrindole
β-Funaltrexamine
6β-Naltrexol
6β-Naltrexol-d4
Alvimopan
AT-076
Binaltorphimine
BU09059
Buprenorphine
Chlornaltrexamine
Clocinnamox
Cyclazocine
Cyprodime
Diacetylnalorphine [61]
Diprenorphine (M5050)
Fedotozine
J-113,397
JDTic
JTC-801
Levallorphan
LY-2456302
LY-255582
Methylnaltrexone
Naldemedine
Nalfurafine
Nalmefene
Nalmexone [62]
Nalodeine (N-allylnorcodeine) [63]
Naloxazone
Naloxegol
Naloxol
Naloxonazine
Naloxone
Nalorphine
Naltrexone
Naltriben
Naltrindole
Norbinaltorphimine
Oxilorphan
PF-4455242
(SAHTM)[64]
Samidorphan

Biased ligands[]

6'-Guanidinonaltrindole
7-Hydroxymitragynine
Herkinorin
ICI-199,441
Noribogaine
Oliceridine
RB-64
TRV734

Receptor heteromer targeting ligands[]

6'-GNTI (δ-κ)
(δ-μ)^[6]
(κ-μ)^[7]
IBNtxA (μ1G-NOP)

Uncategorized opioids[]

Alimadol
Amentoflavone
Anilopam [65] +HCl
Asimadoline
Cyproterone acetate
FE 200665
Fedotozine
HZ-2
Kolokol-1
Matrine
MCOPPB
Menthol
Nalfurafine
Nalorphine
Nalorphine dinicotinate
PZM21
Proglumide
SoRI-9409
Spiradoline
SR-16435

Structures

Uncategorized opioids
Alimadol	Anilopam	Asimadoline
FE 200665	Fedotozine	MCOPPB
Nalfurafine	Nalodeine	Nalorphine	Nalorphine dinicotinate
SoRI-9409

Combination drug formulations containing opioids[]

Buprenorphine/naloxone
Buprenorphine/samidorphan (ALKS-5461)
Co-codamol (codeine phosphate/paracetamol)
Co-codaprin (codeine phosphate/aspirin)
Co-dydramol (dihydrocodeine tartrate/paracetamol)
Co-proxamol (dextropropoxyphene/paracetamol)
Fentanyl/fluanisone
Hydrocodone/ibuprofen
Hydrocodone/paracetamol
Loperamide/simethicone
Morphine/naltrexone
Naltrexone/bupropion
Oxycodone/aspirin
Oxycodone/naloxone
Oxycodone/paracetamol

References[]

^ ChemIndex CAS Registry Number 3371-56-0
^ ChemIndex CAS Registry Number 509-56-8
^ ChemIndex CAS Registry Number 63715-94-6
^ NCBI PubChem SID 750205
^ chembase^{[permanent dead link]} cbid_346222
^ Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
^ Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.

External links[]

Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740

[1] ChemIndex CAS Registry Number 3371-56-0

[2] ChemIndex CAS Registry Number 509-56-8

[3] ChemIndex CAS Registry Number 63715-94-6

[4] NCBI PubChem SID 750205

[5] se^{[permanent dead link]} cbid_346222

[pmid23818586-6] Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.

[pmid21385944-7] Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t Opioid receptor modulators
MOR	Agonists (abridged; see here for a full list): 3-HO-PCP 7-Hydroxymitragynine α-Chlornaltrexamine Acetyldihydrocodeine Acetylfentanyl Acrylfentanyl Adrenorphin (metorphamide) AH-7921 Akuammicine Alfentanil Anileridine Apparicine β-Endorphin Benzhydrocodone Benzylmorphine Bezitramide Biphalin Buprenorphine Butorphan Butorphanol Butyrfentanyl BW373U86 Carfentanil Casokefamide Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene) Dezocine Dimenoxadol Dimethylaminopivalophenone Eluxadoline Diamorphine (heroin) Dihydrocodeine Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine Fentanyl Fluorophen Frakefamide Furanylfentanyl Hemorphin-4 Herkinorin Hodgkinsine Hydrocodone Hydromorphinol Hydromorphone IBNtxA Ketamine Ketobemidone Kratom Laudanosine Lefetamine Leu-enkephalin Levacetylmethadol Levomethorphan Levorphanol Loperamide LS-115509 Matrine Meptazinol Met-enkephalin (metenkefalin) Methadone Metkefamide Metopon Mitragynine Mitragynine pseudoindoxyl Morphiceptin Morphine Nalbuphine Nalmexone Naltalimide NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine OM-3-MNZ Oripavine Oxycodone Oxymorphazone Oxymorphone Papaver somniferum (opium) Pentazocine Pericine Pethidine (meperidine) Phenazocine Phencyclidine Piminodine Piritramide Prodine Propiram PZM21 Racemethorphan Racemorphan Remifentanil SC-17599 Sinomenine Sufentanil Tapentadol Tetrahydropapaveroline Thebaine Thienorphine Tianeptine Tilidine Tramadol Trimebutine TRIMU 5 TRV734 U-47700 Valorphin Viminol Xorphanol PAMs: Antagonists: (3S,4S)-Picenadol 2-(S)-N,N-(R)-Viminol 4-Caffeoyl-1,5-quinide 4',7-Dihydroxyflavone 6β-Naltrexol 6β-Naltrexol-d4 18-MC β-Chlornaltrexamine β-Funaltrexamine Akuammine Alvimopan AM-251 Apigenin AT-076 Axelopran Bevenopran Catechin Catechin gallate Clocinnamox CTAP Cyprodime Diacetylnalorphine Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 Methylnaltrexone Naldemedine Nalmefene Nalodeine (N-allylnorcodeine) Nalorphine Nalorphine dinicotinate Naloxazone Naloxegol Naloxol Naloxonazine Naloxone Naltrexone Naltrindole Naringenin Noribogaine Oxilorphan Pawhuskin A Rimonabant Quadazocine Samidorphan Taxifolin Unknown/unsorted: Cannabidiol Coronaridine Cyproterone acetate Tabernanthine Tetrahydrocannabinol
DOR	Agonists: 6'-GNTI 7-SIOM Alazocine (SKF-10047) Amoxapine β-Endorphin Biphalin BU-48 Butorphan Butorphanol BW373U86 Casokefamide Cebranopadol Codeine Cyclazocine DADLE Deltorphin A Deltorphin I Desmethylclozapine Desmetramadol (desmethyltramadol) Dezocine Diamorphine (heroin) Dihydroetorphine Dihydromorphine DPDPE DPI-221 DPI-3290 Ethylketazocine Etorphine Fentanyl Fluorophen Hemorphin-4 Hydrocodone Hydromorphone Ibogaine Isomethadone Kratom Laudanosine Leu-enkephalin Levomethorphan Levorphanol Lofentanil Met-enkephalin (metenkefalin) Metazocine Metkefamide Mitragynine Mitragynine pseudoindoxyl Morphine N-Phenethyl-14-ethoxymetopon Norbuprenorphine Oripavine Oxycodone Oxymorphone Pethidine (meperidine) Proglumide Racemethorphan Racemorphan RWJ-394674 Samidorphan SNC-80 TAN-67 (SB-205,607) Thebaine Thiobromadol (C-8813) Tonazocine Tramadol Xorphanol Zenazocine Antagonists: 4',7-Dihydroxyflavone 6β-Naltrexol 6β-Naltrexol-d4 β-Chlornaltrexamine Apigenin AT-076 Axelopran Bevenopran Catechin Catechin gallate Clocinnamox Diacetylnalorphine Diprenorphine ECG EGC Eluxadoline Epicatechin LY-255582 Methylnaltrexone Nalmefene Nalorphine Naltrexone Naltriben Naltrindole Naloxone Naringenin Noribogaine Pawhuskin A Quadazocine SoRI-9409 Taxifolin Thienorphine Unknown/unsorted: 18-MC Cannabidiol Coronaridine Cyproterone acetate Tabernanthine Tetrahydrocannabinol
KOR	Agonists: 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine Adrenorphin (metorphamide) Akuammicine Alazocine (SKF-10047) Asimadoline Big dynorphin Bremazocine BRL-52537 Butorphan Butorphanol BW373U86 Cebranopadol Ciprefadol CR665 Cyclazocine Cyclorphan Cyprenorphine Desmetramadol (desmethyltramadol) Diamorphine (heroin) Diacetylnalorphine Difelikefalin Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Ethylketazocine Etorphine Fedotozine Fentanyl Gemazocine GR-89696 Hemorphin-4 Herkinorin HS665 Hydromorphone HZ-2 Ibogaine ICI-199,441 ICI-204,448 Ketamine Ketazocine Laudanosine Leumorphin (dynorphin B-29) Levallorphan Levomethorphan Levorphanol Lofentanil LPK-26 Lufuradom Matrine Menthol Metazocine Metkefamide Mianserin Mirtazapine Morphine Moxazocine Nalbuphine Nalfurafine Nalmefene Nalodeine (N-allylnorcodeine) Nalorphine Naltriben Niravoline Norbuprenorphine Norbuprenorphine-3-glucuronide Noribogaine Norketamine Oripavine Oxilorphan Oxycodone Pentazocine Pethidine (meperidine) Phenazocine Proxorphan Racemethorphan Racemorphan RB-64 Salvinorin A (salvia) Salvinorin B ethoxymethyl ether Salvinorin B methoxymethyl ether Samidorphan Spiradoline (U-62,066) Thienorphine Tifluadom Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-69,593 Xorphanol Antagonists: 4',7-Dihydroxyflavone 5'-GNTI 6'-GNTI 6β-Naltrexol 6β-Naltrexol-d4 β-Chlornaltrexamine Buprenorphine/samidorphan Amentoflavone Apigenin AT-076 Aticaprant Axelopran Binaltorphimine BU09059 Buprenorphine Catechin Catechin gallate CERC-501 (LY-2456302) Clocinnamox Dezocine EGC ECG Epicatechin Hyperoside JDTic LY-255582 LY-2459989 Methylnaltrexone Naloxone Naltrexone Naltrindole Naringenin Norbinaltorphimine Noribogaine Pawhuskin A PF-4455242 RB-64 Quadazocine Taxifolin Zyklophin Unknown/unsorted: Akuammicine Akuammine Coronaridine Cyproterone acetate Ibogamine Tabernanthine
NOP	Agonists: Buprenorphine Cebranopadol Dihydroetorphine Etorphine Levomethorphan Levorphanol MCOPPB NNC 63-0532 Nociceptin (orphanin FQ) Norbuprenorphine Racemethorphan Racemorphan Ro64-6198 SR-16435 Sunobinop (S-117957) Antagonists: AT-076 BTRX-246040 (LY-2940094) J-113,397 JTC-801 SB-612,111 Thienorphine
Unsorted	β-Casomorphins Amidorphin Cytochrophin-4 Gliadorphin (gluteomorphin) Gluten exorphins Hemorphins Kava constituents NEM Neoendorphins Nepetalactone (catnip) Rubiscolins
Others	Enkephalinase inhibitors: Amastatin Candoxatril D -Phenylalanine Ecadotril (sinorphan) Kelatorphan Racecadotril (acetorphan) RB-101 RB-120 RB-3007 Selank Semax Spinorphin Thiorphan Tynorphin Ubenimex (bestatin) Propeptides: β-Lipotropin (proendorphin) Prodynorphin Proenkephalin Proopiomelanocortin (POMC) Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)

List of opioids

Opium and poppy straw derivatives[]

Crude opiate extracts whole opium products[]

Natural opiates[]

Opium alkaloids[]

Alkaloid salts mixtures[]

Semisynthetics including Bentley compounds[]

Morphine family[]

3,6-diesters of morphine[]

Codeine-dionine family[]

Morphinones and morphols[]

Morphides[]

Dihydrocodeine series[]

Nitrogen morphine derivatives[]

Hydrazones[]

Halogenated morphine derivatives[]

Active opiate metabolites[]

Morphinans[]

Morphinan series[]

Others[]

Benzomorphans[]

4-Phenylpiperidines[]

Pethidines (meperidines)[]

Prodines[]

Ketobemidones[]

Others[]

Open chain opioids[]

Amidones[]

Methadols[]

Moramides[]

Thiambutenes[]

Phenalkoxams[]

Ampromides[]

Others[]

Anilidopiperidines[]

Oripavine derivatives[]

Phenazepanes[]

Pirinitramides[]

Benzimidazoles[]

Indoles[]

Beta-Amino Ketones[]

Diphenylmethylpiperazines[]

Opioid peptides[]

Dynorphins[]

Endomorphins[]

Endorphins[]

Enkephalins[]

Propeptides[]

Others / unknown[]

Others[]

Opioid antagonists and inverse agonists[]

Biased ligands[]

Receptor heteromer targeting ligands[]

Uncategorized opioids[]

Combination drug formulations containing opioids[]

See also[]

References[]

External links[]