Oxypertine

Oxypertine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	N05AE01 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	show IUPAC name
CAS Number	153-87-7 ;
PubChem CID	4640;
ChemSpider	4479 ;
UNII	5JGL4G25R7;
KEGG	D01219 ;
CompTox Dashboard (EPA)	DTXSID20165185 ;
ECHA InfoCard	100.005.291
Chemical and physical data
Formula	C23H29N3O2
Molar mass	379.504 g·mol−1
3D model (JSmol)	Interactive image;
	show SMILES
	show InChI
	(what is this?)

Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.^[1] It was also evaluated for the treatment of anxiety at a dosage of 20 mg per day.^[2] Chemically, it is an indole and phenylpiperazine derivative.^[3] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.^[4] Its structure is similar to solypertine and milipertine.

References[]

^ Hall, Chapman and; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.
^ Somohano MD, Broissin MC, Sobrino z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80.
^ Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurol Psychiatr Belg (in French). 68 (2): 116–27. PMID 4972600.
^ Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift für Zellforschung und mikroskopische Anatomie. 101 (3): 448–62. doi:10.1007/BF00335580. PMID 5362847. S2CID 32583722.

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[isbn0-412-54090-8-1] Hall, Chapman and; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.

[2] Somohano MD, Broissin MC, Sobrino z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80.

[pmid4972600-3] Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurol Psychiatr Belg (in French). 68 (2): 116–27. PMID 4972600.

[pmid5362847-4] Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift für Zellforschung und mikroskopische Anatomie. 101 (3): 448–62. doi:10.1007/BF00335580. PMID 5362847. S2CID 32583722.

[1]

[2]

[3]

[4]

show v t Antipsychotics (N05A)
Typical	Butyrophenones: Benperidol Bromperidol Droperidol Haloperidol^# Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines: Fluspirilene Penfluridol Pimozide Phenothiazines: Acetophenazine Butaperazine Carphenazine (carfenazine)^‡ Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Levomepromazine (methotrimeprazine) Mesoridazine Perazine Periciazine Perphenazine Piperacetazine Pipotiazine Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes: Chlorprothixene Clopenthixol Flupentixol Tiotixene (thiothixene) Zuclopenthixol
Disputed	Benzamides: Amisulpride Levosulpiride Nemonapride Remoxipride^‡ Sulpiride Sultopride Tiapride Veralipride^‡ Butyrophenones: Melperone Tricyclics: Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Others: Molindone
Atypical	Benzisoxazole/benzisothiazoles: Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone^# Ziprasidone Butyrophenones: Lumateperone Phenylpiperazines/quinolinones: Aripiprazole Aripiprazole lauroxil Brilaroxazine^† Brexpiprazole Cariprazine Tricyclics: Asenapine Clozapine^# Olanzapine Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole
Others	Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	N05AE01 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
show IUPAC name 5,6-Dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
CAS Number	153-87-7^Y
PubChem CID	4640
ChemSpider	4479^N
UNII	5JGL4G25R7
KEGG	D01219^Y
CompTox Dashboard (EPA)	DTXSID20165185
ECHA InfoCard	100.005.291
Chemical and physical data
Formula	C₂₃H₂₉N₃O₂
Molar mass	379.504 g·mol⁻¹
3D model (JSmol)	Interactive image
show SMILES CC1=C(C2=CC(=C(C=C2N1)OC)OC)CCN3CCN(CC3)C4=CC=CC=C4
show InChI InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3^N Key:XCWPUUGSGHNIDZ-UHFFFAOYSA-N^N
^NY (what is this?)