Pantetheine hydrolase

In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction

(R)-pantetheine + H₂O ${\displaystyle \rightleftharpoons }$ (R)-pantothenate + 2-aminoethanethiol

Thus, the two substrates of this enzyme are (R)-pantetheine and H₂O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1. This enzyme participates in .

References[]

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• Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533.
• Pace HC, Brenner C (2001). "The nitrilase superfamily: classification, structure and function". Genome Biol. 2 (1): REVIEWS0001. doi:10.1186/gb-2001-2-1-reviews0001. PMC 150437. PMID 11380987.