Phthalyl amidase
| phthalyl amidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.79 | ||||||||
| CAS no. | 169150-79-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a phthalyl amidase (EC 3.5.1.79) is an enzyme that catalyzes the chemical reaction
- a phthalylamide + H2O phthalic acid + a substituted amine
Thus, the two substrates of this enzyme are and H2O, whereas its two products are phthalic acid and .
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is phthalyl-amide amidohydrolase.
References[]
- M (1996). "Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis". J. Mol. Catal., B Enzym. 2: 53–69. doi:10.1016/1381-1177(96)00011-2.
- Zmijewski MJ; Briggs, Barbara S.; Evans, Robert; Muth, William L.; Vangala, Surya; Zmijewski, Milton J. (1996). "o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst". Biotechnol. Lett. 18: 875–880. doi:10.1007/BF00154613.
- Costello C, Kreuzman A, Zmijewski M (1996). "Selective deprotection of phthalyl protected proteins". Tetrahedron Lett. 37: 7469–7472. doi:10.1016/0040-4039(96)01752-2.
- Briggs BS, Zmijewski MJ (1995). "Enzyme from microbial source: phthalyl amidase". Chem. Abstr. 123: 25010.
Categories:
- EC 3.5.1
- Enzymes of unknown structure
- EC 3.5 stubs