Pipoxizine

Pipoxizine
Clinical data
ATC code	None;
Identifiers
	show IUPAC name
CAS Number	55837-21-3;
PubChem CID	68750;
ChemSpider	61995;
UNII	B9A98D632Z;
Chemical and physical data
Formula	C24H31NO3
Molar mass	381.516 g·mol−1
3D model (JSmol)	Interactive image;
	show SMILES
	show InChI

Pipoxizine (INN) is a first-generation antihistamine as well as serotonin antagonist of the diphenylmethylpiperazine group related to hydroxyzine.^[1]^[2] It was investigated as a bronchodilator but was never marketed.^[1]^[3]^[4]

References[]

^ Jump up to: ^a ^b C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1619–. ISBN 978-0-412-46630-4.
^ World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O. ISBN 9789240560369.
^ Brunner A, Gartmann J, Studler H. "Pipoxizine, a New Bronchodilator". Lung. 154 (2): 143.
^ Neukirch F, Korobaeff M, Verdier F, Timsit G, Fay M, Drutel P (1978). "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]". Rev Inst Hyg Mines (Hasselt) (in French). 33 (4): 191–5. PMID 45187.

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[GanellinTriggle1996-1] Jump up to: ^a ^b C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1619–. ISBN 978-0-412-46630-4.

[Organization1988-2] World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O. ISBN 9789240560369.

[Brunner1997-3] Brunner A, Gartmann J, Studler H. "Pipoxizine, a New Bronchodilator". Lung. 154 (2): 143.

[pmid45187-4] Neukirch F, Korobaeff M, Verdier F, Timsit G, Fay M, Drutel P (1978). "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]". Rev Inst Hyg Mines (Hasselt) (in French). 33 (4): 191–5. PMID 45187.

[1]

[2]

[3]

[4]

show v t Histamine receptor modulators
H₁	Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT L-Histidine UR-AK49 Antagonists: First-generation: 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cloperastine Cyclizine Cyproheptadine Dacemazine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etodroxizine Etybenzatropine (ethylbenztropine) Etymemazine Fenethazine Flunarizine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Medrylamine Mepyramine (pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Orphenadrine Oxatomide Oxomemazine Perlapine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Pipoxizine Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine Second/third-generation: Acrivastine Astemizole Azelastine Bepotastine Bilastine Cetirizine Clemastine Clemizole Clobenztropine Desloratadine Ebastine Emedastine Epinastine Fexofenadine Ketotifen Latrepirdine Levocabastine Levocetirizine Loratadine Mebhydrolin Mizolastine Moxastine Olopatadine Quifenadine (phencarol) Rupatadine Setastine Talastine Terfenadine Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline) Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine) Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene) Unknown/unsorted:
H₂	Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49 Antagonists: Burimamide Cimetidine Ebrotidine Famotidine Lafutidine Lavoltidine (loxtidine) Lupitidine Metiamide Niperotidine Nizatidine Oxmetidine Ranitidine Roxatidine Sufotidine Zolantidine
H₃	Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L-Histidine Methimepip Proxyfan Antagonists: A-349821 A-423579 ABT-239 Betahistine Burimamide Ciproxifan Clobenpropit Conessine GSK-189254 Impentamine Iodophenpropit JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681
H₄	Agonists: 4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430 Antagonists: JNJ-7777120 Mianserin Thioperamide Toreforant VUF-6002
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors

Clinical data

ATC code	None
Identifiers
show IUPAC name 2-(2-{2-[4-(Diphenylmethylene)-1-piperidinyl]ethoxy}ethoxy)ethanol
CAS Number	55837-21-3
PubChem CID	68750
ChemSpider	61995
UNII	B9A98D632Z
Chemical and physical data
Formula	C₂₄H₃₁NO₃
Molar mass	381.516 g·mol⁻¹
3D model (JSmol)	Interactive image
show SMILES c1ccc(cc1)C(=C2CCN(CC2)CCOCCOCCO)c3ccccc3
show InChI InChI=1S/C24H31NO3/c26-16-18-28-20-19-27-17-15-25-13-11-23(12-14-25)24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,26H,11-20H2 Key:SCMPXORBOTWFTI-UHFFFAOYSA-N