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Tolonidine
Names
Preferred IUPAC name
N -(2-Chloro-4-methylphenyl)-4,5-dihydro-1H -imidazol-2-amine
Identifiers
CAS Number
3D model (JSmol )
ChemSpider
KEGG
UNII
InChI=1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)
N Key: KWBTZIFLQYYPTH-UHFFFAOYSA-N
N InChI=1/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)
Key: KWBTZIFLQYYPTH-UHFFFAOYAF
CC1=CC(=C(C=C1)NC2=NCCN2)Cl
Properties
Chemical formula
C10 H12 ClN3
Molar mass
209.67538
Pharmacology
ATC code
C02AC04 (WHO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N what is Y N
Infobox references
Chemical compound
Tolonidine is an antihypertensive .[1] [2] [3]
See also [ ] References [ ]
^ Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate". Arzneimittel-Forschung . 25 (10): 1557–61. PMID 1243037 . ^ Cosnier, D.; Labrid, C.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis". Arzneimittel-Forschung . 25 (11): 1802–6. PMID 1243090 . ^ Cosnier, D.; Hache, J.; Labrid, C.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity". Arzneimittel-Forschung . 25 (12): 1926–33. PMID 3186 .
Sympatholytics α-adrenergic vasoconstriction )
Central
Peripheral
Indirect
Monoamine oxidase inhibitors VMAT inhibitors
Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine Tyrosine hydroxylase inhibitors
Direct
Other antagonists
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
α1
Agonists Antagonists
Abanoquil Ajmalicine Alfuzosin Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )Benoxathian Beta blockers (e.g., adimolol , amosulalol , arotinolol , carvedilol , eugenodilol , labetalol )Buflomedil Bunazosin Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., acetergamine , ergotamine , dihydroergotamine , lisuride , nicergoline , terguride )Etoperidone Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )Trimazosin Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Urapidil WB-4101 Zolertine
α2
Agonists Antagonists
1-PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan Ketanserin Lisuride mCPP Mianserin Mirtazapine NAN-190 Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine Setiptiline Spegatrine Spiroxatrine Sunepitron Terguride Tolazoline Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Yohimbine
β
See also: Receptor/signaling modulators Dopaminergics Serotonergics Monoamine reuptake inhibitors Monoamine releasing agents Monoamine metabolism modulators Monoamine neurotoxins
Categories :
Alpha-2 adrenergic receptor agonists Antihypertensive agents Chloroarenes Imidazolines Antihypertensive agent stubs Hidden categories:
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