UTP—hexose-1-phosphate uridylyltransferase
UTP:galactose-1-phosphate uridylyltransferase | |||
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Identifiers | |||
EC no. | 2.7.7.10 | ||
CAS no. | 9016-11-9 | ||
Databases | |||
IntEnz | IntEnz view | ||
BRENDA | BRENDA entry | ||
ExPASy | NiceZyme view | ||
KEGG | KEGG entry | ||
MetaCyc | metabolic pathway | ||
PRIAM | profile | ||
PDB structures | RCSB PDB PDBe PDBsum | ||
Gene Ontology | AmiGO / QuickGO | ||
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In enzymology, an UTP—hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) is an enzyme that catalyzes the chemical reaction
- UTP + alpha-D-galactose 1-phosphate diphosphate + UDP-galactose
Thus, the two substrates of this enzyme are UTP and , whereas its two products are diphosphate and UDP-galactose.
Enzyme family[]
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.
Structural studies[]
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GUP, 1GUQ, and 1HXP.
References[]
- ISSELBACHER KJ (1958). "A mammalian uridinediphosphate galactose pyrophosphorylase". J. Biol. Chem. 232 (1): 429–44. PMID 13549431.
- KALCKAR HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta. 12 (1–2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.
- Lee L, Kimura A, Tochikura T (October 1979). "Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum". J. Biochem. Tokyo. 86 (4): 923–8. doi:10.1093/oxfordjournals.jbchem.a132624. PMID 500588.
- Lobelle-Rich PA, Reeves RE (1983). "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica". Mol. Biochem. Parasitol. 7 (2): 173–82. doi:10.1016/0166-6851(83)90043-9. PMID 6304512.
- EC 2.7.7
- Enzymes of known structure
- EC 2.7 stubs