From Wikipedia, the free encyclopedia
Alovudine Other names Fluorothymidine ATC code CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) Formula C 10 H 13 F N 2 O 4 Molar mass 244.222 g·mol−1 3D model (JSmol )
O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H](F)C2)CO
InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1
Y Key:UXCAQJAQSWSNPQ-XLPZGREQSA-N
Y
N Y (what is this?)
Alovudine (fluorothymidine ) is an antiviral agent which was being developed by Medivir . It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.[1]
See also [ ]
References [ ]
Antiviral drugs :
antiretroviral drugs used against
HIV (primarily
J05 )
Entry/fusion inhibitors (Discovery and development ) Reverse-transcriptase inhibitors (RTIs)
Nucleoside and nucleotide (NRTI) Non-nucleoside (NNRTI) (Discovery and development )
1st generation 2nd generation
Integrase inhibitors (Integrase strand transfer inhibitors (INSTI))Maturation inhibitors Protease Inhibitors (PI) (Discovery and development )
1st generation 2nd generation
Combined formulations Pharmacokinetic boosters Experimental agents
Uncoating inhibitors Transcription inhibitors Translation inhibitors BNAbs Capsid inhibitors Other Failed agents
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
°
DHHS recommended initial regimen options .
◊ Formerly or rarely used agent.
DNA virus antivirals (primarily
J05 , also
S01AD and
D06BB )
Baltimore I
Herpesvirus
DNA-synthesis inhibitor
TK activated
Not TK activated
Other
HPV /MC Vaccinia Poxviridae
Hepatitis B (VII)Multiple/general
Nucleic acid inhibitors Interferon Multiple/unknown
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
RNA virus antivirals (primarily
J05 , also
S01AD and
D06BB )
Hepatitis C
NS3 /4A protease inhibitors (–previr)NS5A inhibitors (–asvir)NS5B RNA polymerase inhibitors (–buvir)Combination drugs
Hepatitis D Picornavirus Anti-influenza agents Multiple/general
Interferon Multiple/unknown
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
Categories :
Drugs not assigned an ATC code Antiviral drugs Pyrimidinediones Organofluorides Abandoned drugs Antiinfective agent stubs Hidden categories:
Articles with changed CASNo identifier Chemical pages without DrugBank identifier Drugs with no legal status Drugboxes which contain changes to verified fields All stub articles