Atrolysin B
Atrolysin B | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.24.41 | ||||||||
CAS no. | 172306-48-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Atrolysin B (EC 3.4.24.41, Crotalus atrox metalloendopeptidase b, hemorrhagic toxin b, Ht-b) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -Ser bonds in glucagon
This enzyme is present in the western diamondback rattlesnake (Crotalus atrox).
References[]
- ^ Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID 210790.
- ^ Bjarnason JB, Hamilton D, Fox JW (May 1988). "Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom". Biological Chemistry Hoppe-Seyler. 369 Suppl: 121–9. PMID 3060135.
External links[]
- Atrolysin+B at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- EC 3.4.24