BD-1047

BD-1047
Clinical data
ATC code	none;
Identifiers
	IUPAC name N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine;
CAS Number	138356-20-4 ;
PubChem CID	188914;
IUPHAR/BPS	6680;
ChemSpider	164154 ;
UNII	1S3X75QGDO;
ChEMBL	ChEMBL143360 ;
CompTox Dashboard (EPA)	DTXSID70160640 ;
Chemical and physical data
Formula	C13H20Cl2N2
Molar mass	275.22 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(CCN(C)CCN(C)C)cc1Cl;
	InChI InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3 ; Key:MGVRNMUKTZOQOW-UHFFFAOYSA-N ;
	(what is this?)

BD-1047 is a sigma receptor antagonist, selective for the σ₁ subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.^[1]^[2]

More recent studies also suggest a novel role for BD-1047 in attenuating ethanol-induced neurotoxicity in vitro, and additional research is being conducted on this compound as a possible pharmacotherapy for alcohol use disorder (AUD) ^[3]

References[]

^ Skuza G, Rogóz Z (2006). "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports. 58 (5): 626–35. PMID 17085854.
^ Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (November 2008). "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology. 109 (5): 879–89. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.
^ Reynolds AR, Saunders MA, Prendergast MA (2016). "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3". Alcohol Clin Exp Res. 40 (7): 1454–61. doi:10.1111/acer.13097. PMC 6662182. PMID 27177604.

This drug article relating to the nervous system is a stub. You can help Wikipedia by .

[pmid17085854-1] Skuza G, Rogóz Z (2006). "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports. 58 (5): 626–35. PMID 17085854.

[pmid18946301-2] Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (November 2008). "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology. 109 (5): 879–89. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.

[pmid27177604-3] Reynolds AR, Saunders MA, Prendergast MA (2016). "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3". Alcohol Clin Exp Res. 40 (7): 1454–61. doi:10.1111/acer.13097. PMC 6662182. PMID 27177604.

[1]

[2]

[3]

v t Sigma receptor modulators
σ₁	Agonists: 3-PPP 4-PPBP 5-MeO-DMT Alazocine (SKF-10047) Amantadine Arketamine BD-1052 Blarcamesine Captodiame Citalopram CGRP Cloperastine Cocaine Cutamesine (SA-4503) Cyclazocine Dehydroepiandrosterone (DHEA) (prasterone) Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate) Dextrallorphan Dextromethorphan (DXM) Dextrorphan (DXO) Dimemorfan Dimethyltryptamine (DMT) Ditolylguanidine (DTG) Donepezil Eliprodil Escitalopram Fabomotizole (afobazole) Fluoxetine Fluvoxamine Ifenprodil Igmesine (JO-1784) Ketamine L-687384 MDMA (midomafetamine) Memantine Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine Opipramol Pentazocine Pentoxyverine (carbetapentane) PRE-084 Pregnenolone Pregnenolone sulfate Pridopidine Racemethorphan (methorphan) Racemorphan (morphanol) Antagonists: 3-PPP AC-927 BD-1008 BD-1031 BD-1047 BD-1060 BD-1063 BD-1067 BMY-14802 (BMS-181100) CM-156 E-52862 (S1RA) Haloperidol NE-100 Panamesine (EMD-57455) Pentazocine Progesterone Rimcazole (BW-234U) Sertraline Allosteric modulators: Phenytoin; Positive: Methylphenylpiracetam Unknown/unsorted: 3-MeO-PCP 4C-T-2 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Amitriptyline Chlorpromazine Clemastine Clomipramine Clorgiline D-Deprenyl DiPT DPT Ibogaine Imipramine Nemonapride Noribogaine RS-67,333 RTI-55 Saffron Safinamide Selegiline Trifluoperazine W-18 YKP10A
σ₂	Agonists: 3-PPP Arketamine BD-1047 BD1063 Ditolylguanidine (DTG) Haloperidol Ifenprodil Ketamine MDMA (midomafetamine) Methamphetamine Opipramol PB-28 Phencyclidine Siramesine (Lu 28-179) Antagonists: AC-927 BD-1008 BD-1067 CM-156 MIN-101 Panamesine (EMD-57455) Unknown/unsorted: 3-MeO-PCE 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Clemastine DiPT DPT Ibogaine Nemonapride Nepinalone Noribogaine Pentazocine RS-67,333 Safinamide TMA W-18
Unsorted	Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists: Lamotrigine Naloxone Allosteric modulators: SKF-83959 Unknown/unsorted: 18-Methoxycoronaridine Butaclamol Caramiphen Chlorphenamine (chlorpheniramine) Chlorpromazine Cinnarizine Clocapramine Dezocine Hypericin (St. John's wort) Fluphenazine Gevotroline (WY-47384) Mepyramine (pyrilamine) Molindone Perphenazine Pimozide Proadifen Promethazine Propranolol Quinidine Remoxipride Tiospirone (BMY-13859) Venlafaxine
See also: Receptor/signaling modulators

Clinical data

ATC code	none
Identifiers
IUPAC name N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine
CAS Number	138356-20-4^N
PubChem CID	188914
IUPHAR/BPS	6680
ChemSpider	164154^Y
UNII	1S3X75QGDO
ChEMBL	ChEMBL143360^Y
CompTox Dashboard (EPA)	DTXSID70160640
Chemical and physical data
Formula	C₁₃H₂₀Cl₂N₂
Molar mass	275.22 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(CCN(C)CCN(C)C)cc1Cl
InChI InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3^Y Key:MGVRNMUKTZOQOW-UHFFFAOYSA-N^Y
^NY (what is this?)