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Fourphit
Names
Preferred IUPAC name
4-Isothiocyanato-1-(1-phenylcyclohexyl)piperidine
Identifiers
CAS Number
104639-01-2 N
3D model (JSmol )
ChemSpider
InChI=1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
Key: QAHYIAVTWZVTMY-UHFFFAOYSA-N
InChI=1/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
Key: QAHYIAVTWZVTMY-UHFFFAOYAR
c1ccc(cc1)C2(CCCCC2)N3CCC(CC3)N=C=S
Properties
Chemical formula
C 18 H 24 N 2 S
Molar mass
300.46 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Fourphit (4-isothiocyanato-1-[1-phenylcyclohexyl]piperidine ) is a covalent binding NMDA antagonist , dopaminergic and sigma receptor agonist.[1]
See also [ ]
References [ ]
^ Schweri, M. M.; De Costa, B. R.; Rice, K. C. (1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacology Biochemistry and Behavior . 60 (3): 615–23. doi :10.1016/s0091-3057(98)00040-9 . PMID 9678644 . S2CID 1151532 .
Pharmacodynamics
AMPAR
Antagonists:
Becampanel
Caroverine
CNQX
Dasolampanel
DNQX
Fanapanel (MPQX)
Kaitocephalin
Kynurenic acid
Kynurenine
Licostinel (ACEA-1021)
NBQX
Selurampanel
Tezampanel
Theanine
Topiramate
Zonampanel ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Cyclopropane
Enflurane
Ethanol (alcohol)
Evans blue
GYKI-52466
Halothane
Irampanel
Isoflurane
Perampanel
Pregnenolone sulfate
Sevoflurane
Talampanel ; Unknown/unsorted antagonists: Minocycline
KAR
Agonists: Main site agonists:
5-Iodowillardiine
AMPA
Domoic acid
Glutamate
Ibotenic acid
Kainic acid
Proline
Quisqualic acid
; Positive allosteric modulators: Cyclothiazide
Diazoxide
Enflurane
Halothane
Isoflurane
Antagonists:
CNQX
Dasolampanel
DNQX
Kaitocephalin
Kynurenic acid
Licostinel (ACEA-1021)
NBQX
NS102
Selurampanel
Tezampanel
Theanine
Topiramate
UBP-302 ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Enflurane
Ethanol (alcohol)
Evans blue
Pregnenolone sulfate
NMDAR
See also: Receptor/signaling modulators
Metabotropic glutamate receptor modulators
Glutamate metabolism/transport modulators
Monoamine reuptake inhibitors
DAT (DRIs )
Piperazines: DBL-583
GBR-12783
GBR-12935
GBR-13069
GBR-13098
Nefazodone
Vanoxerine
Pyrrolidines: Diphenylprolinol
MDPV
Naphyrone
Prolintane
Pyrovalerone
NET (NRIs )
Tricyclic antidepressants: Amitriptyline
Butriptyline
Cianopramine
Clomipramine
Desipramine
Dosulepin (dothiepin)
Doxepin
Imipramine
Lofepramine
Melitracen
Nortriptyline
Protriptyline
Trimipramine
Tetracyclic antidepressants: Amoxapine
Maprotiline
Mianserin
Oxaprotiline
Setiptiline
Others: Antihistamines (e.g., brompheniramine , chlorphenamine , pheniramine , tripelennamine )
Antipsychotics (e.g., loxapine , ziprasidone )
Arylcyclohexylamines (e.g., ketamine , phencyclidine )
Dopexamine
Ephenidine
Ginkgo biloba
Indeloxazine
Nefazodone
Opioids (e.g., desmetramadol , methadone , pethidine (meperidine) , tapentadol , tramadol , levorphanol )
SERT (SRIs )
Selective serotonin reuptake inhibitors and serotonin receptor modulators: Etoperidone
Litoxetine
Lubazodone
LY-393558
Quipazine
SB-649915
TGBA01AD
Trazodone
Vilazodone
Vortioxetine
Tricyclic antidepressants: Amitriptyline
Cianopramine
Clomipramine
Cyanodothiepin
Desipramine
Dosulepin (dothiepin)
Doxepin
Imipramine
Lofepramine
Nortriptyline
Pipofezine
Protriptyline
Others:
Amoxapine
Antihistamines (e.g., brompheniramine , chlorphenamine , dimenhydrinate , diphenhydramine , mepyramine (pyrilamine) , pheniramine , tripelennamine )
Antipsychotics (e.g., loxapine , ziprasidone )
Arylcyclohexylamines (e.g., 3-MeO-PCP , esketamine , ketamine , methoxetamine , phencyclidine )
Cyclobenzaprine
Delucemine
Dextromethorphan
Dextrorphan
Efavirenz
Hypidone
Medifoxamine
Mesembrine
Mifepristone
MIN-117 (WF-516)
N-Me-5-HT
Opioids (e.g., dextropropoxyphene , methadone , pethidine (meperidine) , levorphanol , tapentadol , tramadol )
Roxindole
VMATs
Amiodarone
Amphetamines (e.g., amphetamine , methamphetamine , MDMA )
Bietaserpine
Deserpidine
Deutetrabenazine
Dihydrotetrabenazine
Efavirenz
GBR-12935
Ibogaine
Ketanserin
Lobeline
Reserpine
Rose bengal
Tetrabenazine
Valbenazine
Vanoxerine (GBR-12909)
Others
DAT modulators: Agonist-like: SoRI-9804
; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
σ1
Agonists: 3-PPP
4-PPBP
5-MeO-DMT
Alazocine (SKF-10047)
Amantadine
Arketamine
BD-1052
Blarcamesine
Captodiame
Citalopram
CGRP
Cloperastine
Cocaine
Cutamesine (SA-4503)
Cyclazocine
Dehydroepiandrosterone (DHEA) (prasterone )
Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate )
Dextrallorphan
Dextromethorphan (DXM)
Dextrorphan (DXO)
Dimemorfan
Dimethyltryptamine (DMT)
Ditolylguanidine (DTG)
Donepezil
Eliprodil
Escitalopram
Fabomotizole (afobazole)
Fluoxetine
Fluvoxamine
Ifenprodil
Igmesine (JO-1784)
Ketamine
L-687384
MDMA (midomafetamine)
Memantine
Methamphetamine
Methoxetamine
Methylphenidate
Nepinalone
Neuropeptide Y
Noscapine
Opipramol
Pentazocine
Pentoxyverine (carbetapentane)
PRE-084
Pregnenolone
Pregnenolone sulfate
Pridopidine
Racemethorphan (methorphan)
Racemorphan (morphanol)
Allosteric modulators: Phenytoin ; Positive: Methylphenylpiracetam
σ2
Antagonists: AC-927
BD-1008
BD-1067
CM-156
MIN-101
Panamesine (EMD-57455)
Unsorted
Antagonists:
Lamotrigine
Naloxone
Allosteric modulators: SKF-83959
See also: Receptor/signaling modulators
Categories :
Arylcyclohexylamines Dopamine reuptake inhibitors Dissociative drugs NMDA receptor antagonists Piperidines Sigma agonists Isothiocyanates Nervous system drug stubs Hidden categories:
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