From Wikipedia, the free encyclopedia
N -Methyl-PPPAOther names Detrifluoromethylfluoxetine ATC code
N -Methyl-3-phenoxy-3-phenyl-1-propanamine
ChemSpider Formula C 16 H 19 N O Molar mass 241.334 g·mol−1 3D model (JSmol )
InChI=1S/C16H19NO/c1-17-13-12-16(14-8-4-2-5-9-14)18-15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3
Key:DMOUAPYFRKLFHO-UHFFFAOYSA-N
N -Methyl-PPPA , or N -methyl-3-phenoxy-3-phenylpropan-1-amine , is a serotonin-norepinephrine reuptake inhibitor (SNRI) which was developed by Eli Lilly from diphenhydramine in the early 1970s while in search of new antidepressants , but was never marketed.[1] [2] [3] It is closely related structurally to fluoxetine , atomoxetine , and nisoxetine .[1] [2] [3]
See also [ ]
References [ ]
^ a b Francisco Lopez-Munoz; Cecilio Alamo (9 September 2011). Neurobiology of Depression . CRC Press. pp. 132–. ISBN 978-1-4398-3850-1 .
^ a b Walter Sneader (31 October 2005). Drug Discovery: A History . John Wiley & Sons. pp. 416–417. ISBN 978-0-470-01552-0 .
^ a b Wong DT, Bymaster FP, Engleman EA (1995). "Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication". Life Sci . 57 (5): 411–41. doi :10.1016/0024-3205(95)00209-o . PMID 7623609 .
Antidepressants (N06A )
SSRIs
Citalopram
Escitalopram
Fluoxetine #
Fluvoxamine
Indalpine ‡
Paroxetine
Sertraline
Zimelidine ‡
SNRIs NRIs NDRIs
Amineptine ‡
Bupropion
Nomifensine ‡
NaSSAs SARIs SMS Others
Monoamine oxidase inhibitors
Non-selective MAOA -selectiveMAOB -selective
Miscellaneous
Ademetionine (SAMe )
Hypericum perforatum (St. John's Wort)
Oxitriptan (5-HTP )
Rubidium chloride (RbCl)
Tryptophan
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
Monoamine reuptake inhibitors
DAT (DRIs )
NET (NRIs )
Others: Antihistamines (e.g., brompheniramine , chlorphenamine , pheniramine , tripelennamine )
Antipsychotics (e.g., loxapine , ziprasidone )
Arylcyclohexylamines (e.g., ketamine , phencyclidine )
Dopexamine
Ephenidine
Ginkgo biloba
Indeloxazine
Nefazodone
Opioids (e.g., desmetramadol , methadone , pethidine (meperidine) , tapentadol , tramadol , levorphanol )
SERT (SRIs )
Others:
Amoxapine
Antihistamines (e.g., brompheniramine , chlorphenamine , dimenhydrinate , diphenhydramine , mepyramine (pyrilamine) , pheniramine , tripelennamine )
Antipsychotics (e.g., loxapine , ziprasidone )
Arylcyclohexylamines (e.g., 3-MeO-PCP , esketamine , ketamine , methoxetamine , phencyclidine )
Cyclobenzaprine
Delucemine
Dextromethorphan
Dextrorphan
Efavirenz
Hypidone
Medifoxamine
Mesembrine
Mifepristone
MIN-117 (WF-516)
N-Me-5-HT
Opioids (e.g., dextropropoxyphene , methadone , pethidine (meperidine) , levorphanol , tapentadol , tramadol )
Roxindole
VMATs Others See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
Eli Lilly and Company
Corporate directors Products
Adcirca
Alimta
Amyvid
Bamlanivimab
Baqsimi
Baricitinib
Basaglar
Cialis
Cymbalta
Cyramza
Emgality
Erbitux
Etesevimab
Evista
Forteo
Gemzar
Glucagon
Glyxambi
Humalog
Humatrope
Humulin
Jardiance
Jentadueto
Lyumjev
Olumiant
Portrazza
Prozac
Retevmo
Reyvow
Strattera
Symbyax
Synjardy
Taltz
Tradjenta
Trijardy
Trulicity
Verzenio
Xigris
Zyprexa
Categories :
Drugs not assigned an ATC code Antidepressants Eli Lilly and Company brands Serotonin–norepinephrine reuptake inhibitors Nervous system drug stubs Hidden categories:
Infobox drug articles with non-default infobox title Chemical articles without CAS registry number Articles without EBI source Chemical pages without DrugBank identifier Articles without KEGG source Articles without UNII source Drugs with no legal status Articles containing unverified chemical infoboxes All stub articles