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JZ-IV-10
(+)-2-([(3R,4S)-1-methyl-4-(4-chlorophenyl)piperidin-3-yl]methylthio)-N-isopropylacetamide
CAS Number PubChem CID ChemSpider Formula C 18 H 27 Cl N 2 O S Molar mass 354.94 g·mol−1 3D model (JSmol )
Clc1ccc(cc1)[C@H]2CCN(C)C[C@@H]2CSCC(=O)NC(C)C
InChI=1S/C18H27ClN2OS/c1-13(2)20-18(22)12-23-11-15-10-21(3)9-8-17(15)14-4-6-16(19)7-5-14/h4-7,13,15,17H,8-12H2,1-3H3,(H,20,22)/t15-,17-/m1/s1
N Key:GPNABXAHBDYHFE-NVXWUHKLSA-N
N
N Y (what is this?)
JZ-IV-10 is a piperidine derivative related to cocaine which acts as a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor).[1] The eugeroic modafinil was used as a lead to fuel this compound's discovery.[2] [3]
See also [ ]
References [ ]
^ WO 2005041875 , Kozikowski, Alan P. & Zhou, Jia, "Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications", published 2005-05-12, assigned to Georgetown University
^ Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP (November 2004). "Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization" . Journal of Medicinal Chemistry . 47 (24): 5821–4. doi :10.1021/jm040117o . PMC 1395211 . PMID 15537337 .
^ He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP (December 2005). "Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors". Journal of Medicinal Chemistry . 48 (25): 7970–9. doi :10.1021/jm050694s . PMID 16335921 .
Stimulants
Adamantanes
Adapromine
Amantadine
Bromantane
Memantine
Rimantadine
Adenosine antagonists Alkylamines Ampakines Arylcyclohexylamines Benzazepines
6-Br-APB
SKF-77434
SKF-81297
SKF-82958
Cathinones Cholinergics Convulsants Eugeroics Oxazolines Phenethylamines Phenylmorpholines Piperazines
2C-B-BZP
3C-PEP
BZP
CM156
DBL-583
GBR-12783
GBR-12935
GBR-13069
GBR-13098
GBR-13119
MeOPP
MBZP
oMPP
Vanoxerine
Piperidines Pyrrolidines Racetams
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Tropanes Tryptamines Others ATC code : N06B
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GBR-12783
GBR-12935
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GBR-13098
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Others
DAT modulators: Agonist-like: SoRI-9804
; Antagonist-like: SoRI-20041
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
Categories :
Stimulants Carboxamides 4-Phenylpiperidines Chloroarenes Serotonin–norepinephrine–dopamine reuptake inhibitors Nervous system drug stubs Hidden categories:
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