mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate
4-DAMP
Aclidinium bromide (+formoterol )
Abediterol
AF-DX 384
Ambutonium bromide
Anisodamine
Anisodine
Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , dimetindene , diphenhydramine , doxylamine , meclizine , mequitazine , perlapine , phenindamine , pheniramine , phenyltoloxamine , promethazine , propiomazine , triprolidine )
Atropine
Atropine methonitrate
Atypical antipsychotics (e.g., clozapine , fluperlapine , olanzapine (+fluoxetine ), , quetiapine , tenilapine , zotepine )
Benactyzine
Benzatropine (benztropine)
Benzilone
Benzilylcholine mustard
Benzydamine
Biperiden
Bornaprine
Camylofin
CAR-226,086
CAR-301,060
CAR-302,196
CAR-302,282
CAR-302,668
Caramiphen
Cimetropium bromide
Clidinium bromide
Cloperastine
CS-27349
Cyclobenzaprine
Cyclopentolate
Darifenacin
Desfesoterodine
Dexetimide
Dicycloverine (dicyclomine)
Dihexyverine
Difemerine
Diphemanil metilsulfate
Ditran
Drofenine
EA-3167
EA-3443
EA-3580
EA-3834
Emepronium bromide
Etanautine
Etybenzatropine (ethybenztropine)
Fenpiverinium
Fentonium bromide
Fesoterodine
Flavoxate
Glycopyrronium bromide (+beclometasone/formoterol , +indacaterol )
Hexocyclium
Himbacine
Homatropine
Imidafenacin
Ipratropium bromide (+salbutamol )
Isopropamide
Hyoscyamine
Mamba toxin 3
Mamba toxin 7
Mazaticol
Mebeverine
Meladrazine
Mepenzolate
Methantheline
Methoctramine
Methylatropine
Methylhomatropine
Methylscopolamine
Metixene
Muscarinic toxin 7
N-Ethyl-3-piperidyl benzilate
N-Methyl-3-piperidyl benzilate
Nefopam
Octatropine methylbromide (anisotropine methylbromide)
Orphenadrine
Otenzepad (AF-DX 116)
Otilonium bromide
Oxapium iodide
Oxitropium bromide
Oxybutynin
Oxyphencyclimine
Oxyphenonium bromide
PD-102,807
PD-0298029
Penthienate
Pethidine
Phenglutarimide
Phenyltoloxamine
Pipenzolate bromide
Piperidolate
Pirenzepine
Piroheptine
Pizotifen
Poldine
Pridinol
Prifinium bromide
Procyclidine
Profenamine (ethopropazine)
Propantheline bromide
Propiverine
Quinidine
3-Quinuclidinyl thiochromane-4-carboxylate
Revefenacin
Rociverine
Scopolamine (hyoscine)
Scopolamine butylbromide (hyoscine butylbromide)
Sofpironium bromide
Solifenacin
SSRIs (e.g., femoxetine , paroxetine )
Telenzepine
Terodiline
Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )
Tiemonium iodide
Timepidium bromide
Tiotropium bromide
Tofenacin
Tolterodine
Tricyclic antidepressants (e.g., amitriptyline (+perphenazine ), amitriptylinoxide , butriptyline , cidoxepin , clomipramine , desipramine , , dibenzepin , dosulepin (dothiepin) , doxepin , imipramine , lofepramine , nitroxazepine , northiaden (desmethyldosulepin) , nortriptyline , protriptyline , quinupramine , trimipramine )
Tridihexethyl
Trihexyphenidyl
Trimebutine
Tropatepine
Tropicamide
Trospium chloride
Typical antipsychotics (e.g., chlorpromazine , chlorprothixene , cyamemazine (cyamepromazine) , loxapine , mesoridazine , thioridazine )
Umeclidinium bromide (+vilanterol )
WIN-2299
Xanomeline
Precursors (and prodrugs )
Acetyl-coA
Adafenoxate
Choline (lecithin )
Citicoline
Cyprodenate
Dimethylethanolamine
Glycerophosphocholine
Meclofenoxate (centrophenoxine)
Phosphatidylcholine
Phosphatidylethanolamine
Phosphorylcholine
Pirisudanol
See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators
nAChRs
Agonists (and PAMs )Antagonists (and NAMs )
Precursors (and prodrugs )
Acetyl-coA
Adafenoxate
Choline (lecithin )
Citicoline
Cyprodenate
Dimethylethanolamine
Glycerophosphocholine
Meclofenoxate (centrophenoxine)
Phosphatidylcholine
Phosphatidylethanolamine
Phosphorylcholine
Pirisudanol
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators
Calcium
Potassium
Sodium
VGSCs
Blockers
Antiarrhythmics (class I): Ajmaline
Aprindine
Disopyramide
Dronedarone
Encainide
Flecainide
Lidocaine
Lorajmine
Lorcainide
Mexiletine
Moricizine
Pilsicainide
Prajmaline
Procainamide
Propafenone
Quinidine
Sparteine
Tocainide
Analgesics:
DSP-2230
Funapide
PF-05089771
Ralfinamide
Raxatrigine
Toxins: Conotoxins
Neosaxitoxin
Saxitoxin
Tetrodotoxin
Zetekitoxin AB
Others: Buprenorphine
Evenamide
Menthol (mint )
Safinamide
Tricyclic antidepressants
Activators
ENaC
Blockers
Amiloride
Benzamil
Triamterene
Activators
ASICs
Blockers
Amiloride
Aspirin
Ibuprofen
Chloride
CaCCs
Blockers
Crofelemer
DIDS
Ethacrynic acid
Flufenamic acid
Fluoxetine
Furosemide
Glibenclamide
Mefloquine
Mibefradil
Niflumic acid
Activators
CFTR
Unsorted
Others
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
Forms
Nitroxyl anion (NO− ; oxonitrate(1-), hyponitrite anion)
Nitric oxide (NO⋅ ; nitrogen monoxide)
Nitrosonium (NO+ ; nitrosyl cation)
Targets
sGC
Activators/stimulators:
Cinaciguat (BAY 58-2667)
Riociguat
Vericiguat
NO donors (prodrugs )
Nitrates : Diethylene glycol dinitrate (DEGDN)
Erythritol tetranitrate (ETN)
Ethylene glycol dinitrate (EGDN; nitroglycol)
Isosorbide mononitrate (ISMN)
Isosorbide dinitrate (ISDN)
Itramin tosilate
Mannitol hexanitrate
Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
Nicorandil
Nipradilol (K-351)
Nitrate (NO− 3 )
Nitroglycerin (glyceryl trinitrate (GTN))
Pentaerithrityl tetranitrate (PETN)
Propatylnitrate
Propylene glycol dinitrate (PGDN)
Tenitramine
Trolnitrate
Nitroso compounds /nitrites : Nitrite (NO− 2 ) ; O-Nitroso compounds (alkyl nitrites ): Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
Cyclohexyl nitrite
Ethyl nitrite
Isobutyl nitrite (2-methylpropyl nitrite)
Isopropyl nitrite
Methyl nitrite
n -Butyl nitrite
Pentyl nitrite
; S-Nitroso compounds (thionitrites):
S-Nitroso-N-acetylpenicillamine (SNAP)
S-Nitrosoglutathione (GSNO, SNOG)
; N-Nitroso compounds (e.g., nitrosamines ):
Heterocyclic compounds: Furoxans : Furoxan
; : Feprosidnine
Linsidomine (SIN-1)
Molsidomine (SIN-10)
Enzyme (inhibitors )
NOS
nNOS
7-Nitroindazole
Aminoguanidine (pimagedine)
Indazole
Nitroarginine (NNA, NOARG)
Pentamidine isethionate
iNOS
Aminoguanidine (pimagedine)
Canavanine
eNOS
Aminoguanidine (pimagedine)
Nitroarginine (NNA, NOARG)
Unsorted
Asymmetric dimethylarginine (ADMA)
Indospicine
Arginase
chlorogenic acid
ginseng
epicatechin
ornithine
norvaline
lysine
CAMK
Others
Cofactors: NADPH
FAD
FMN
Heme
BH4
CaM
O2
Ca2+
Indirect/downstream NO modulators: ACE inhibitors /AT-II receptor antagonists (e.g., captopril , losartan )
ETB receptor antagonists (e.g., bosentan )
L-Type calcium channel blockers (e.g., dihydropyridines : nifedipine )
Nebivolol (beta blocker )
PDE5 inhibitors (e.g., sildenafil )
non-selective PDE inhibitors (e.g., caffeine )
PDE9 inhibitors (e.g., paraxanthine )
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
Statins (e.g., simvastatin )
See also: Receptor/signaling modulators
σ1
Agonists: 3-PPP
4-PPBP
5-MeO-DMT
Alazocine (SKF-10047)
Amantadine
Arketamine
BD-1052
Blarcamesine
Captodiame
Citalopram
CGRP
Cloperastine
Cocaine
Cutamesine (SA-4503)
Cyclazocine
Dehydroepiandrosterone (DHEA) (prasterone )
Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate )
Dextrallorphan
Dextromethorphan (DXM)
Dextrorphan (DXO)
Dimemorfan
Dimethyltryptamine (DMT)
Ditolylguanidine (DTG)
Donepezil
Eliprodil
Escitalopram
Fabomotizole (afobazole)
Fluoxetine
Fluvoxamine
Ifenprodil
Igmesine (JO-1784)
Ketamine
L-687384
MDMA (midomafetamine)
Memantine
Methamphetamine
Methoxetamine
Methylphenidate
Nepinalone
Neuropeptide Y
Noscapine
Opipramol
Pentazocine
Pentoxyverine (carbetapentane)
PRE-084
Pregnenolone
Pregnenolone sulfate
Pridopidine
Racemethorphan (methorphan)
Racemorphan (morphanol)
Allosteric modulators: Phenytoin ; Positive: Methylphenylpiracetam
σ2
Antagonists: AC-927
BD-1008
BD-1067
CM-156
MIN-101
Panamesine (EMD-57455)
Unsorted
Antagonists:
Lamotrigine
Naloxone
Allosteric modulators: SKF-83959
See also: Receptor/signaling modulators
CAR
Agonists:
Amiodarone
Artemisinin
Carbamazepine
Carvedilol
Chlorpromazine
Chrysin
Clotrimazole
Cyclophosphamide
Cypermethrin
DHEA (prasterone )
Efavirenz
Ellagic acid
Griseofulvin
Methoxychlor
Mifepristone
Nefazodone
Nevirapine
Nicardipine
Permethrin
Phenobarbital
Phenytoin
Pregnanedione (5β-dihydroprogesterone)
Reserpine
Telmisartan
Tolnaftate
Troglitazone
Valproic acid
Antagonists:
3α-Androstenol
AITC
Ethinylestradiol
Meclizine
Okadaic acid
PK-11195
PXR
See also
Receptor/signaling modulators