Chondro-4-sulfatase

In enzymology, a chondro-4-sulfatase (EC 3.1.6.9) is an enzyme that catalyzes the chemical reaction

4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H₂O ${\displaystyle \rightleftharpoons }$ 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate

The 3 substrates of this enzyme are , , and H₂O, whereas its two products are and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-su lfate 4-sulfohydrolase. This enzyme is also called chondroitin-4-sulfatase.

References[]

• Held E, Buddecke E (1967). "[Studies on the chemistry of the arterial wall, XI. Demonstration, purification and properties of a chondroitin-4-sulfatase from bovine aorta]". Hoppe-Seyler's Z. Physiol. Chem. 348 (8): 1047–60. PMID 5595107.
• Roy AB (1976). "Sulphatases, lysosomes and disease". Aust. J. Exp. Biol. Med. Sci. 54 (2): 111–35. doi:10.1038/icb.1976.13. PMID 13772.
• Yamagata T, Saito H, Habuchi O, Suzuki S (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243 (7): 1523–35. PMID 5647268.