Fructose-2,6-bisphosphate 6-phosphatase

In enzymology, a fructose-2,6-bisphosphate 6-phosphatase (EC 3.1.3.54) is an enzyme that catalyzes the chemical reaction

beta-D-fructose 2,6-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ beta-D-fructofuranose 2-phosphate + phosphate

Thus, the two substrates of this enzyme are beta-D-fructose 2,6-bisphosphate and H₂O, whereas its two products are and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase. Other names in common use include fructose 2,6-bisphosphate-6-phosphohydrolase, fructose-2,6-bisphosphate 6-phosphohydrolase, and D-fructose-2,6-bisphosphate 6-phosphohydrolase. This enzyme participates in fructose and mannose metabolism.

References[]

• Purwin C, Laux M, Holzer H (1986). "Fructose 2-phosphate, an intermediate of the dephosphorylation of fructose 2,6-bisposphate with purified yeast enzyme". Eur. J. Biochem. 164: 27–30. doi:10.1111/j.1432-1033.1987.tb10987.x. PMID 2951255.
• Purwin C, Laux M, Holzer H (1987). "Fructofuranose 2-phosphate is the product of dephosphorylation of fructose 2,6-bisphosphate". Eur. J. Biochem. 165 (3): 543–5. doi:10.1111/j.1432-1033.1987.tb11473.x. PMID 3036508.