Hydroxynefazodone

Hydroxynefazodone
Clinical data
Other names	OH-NEF
Pharmacokinetic data
Elimination half-life	1.5–4 hours
Identifiers
	show IUPAC name
CAS Number	98159-82-1 ; 98159-83-2 (dihydrochloride);
PubChem CID	11755137;
ChemSpider	9929840;
UNII	325402PVUU;
CompTox Dashboard (EPA)	DTXSID10471904 ;
Chemical and physical data
Formula	C25H32ClN5O3
Molar mass	486.01 g·mol−1
3D model (JSmol)	Interactive image;
	show SMILES
	show InChI

Hydroxynefazodone is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.^[1]^[2]^[3] It has similar biological activity and a similar elimination half-life (1.5 to 4 hours)^[1] to those of nefazodone, and may contribute significantly to its effects.^[2]^[3]

References[]

^ Jump up to: ^a ^b ^c Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.CS1 maint: multiple names: authors list (link)
^ Jump up to: ^a ^b Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7.
^ Jump up to: ^a ^b Davis R, Whittington R, Bryson HM (1997). "Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression". Drugs. 53 (4): 608–36. doi:10.2165/00003495-199753040-00006. PMID 9098663.

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[SchatzbergNemeroff2017-1] Jump up to: ^a ^b ^c Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.CS1 maint: multiple names: authors list (link)

[PreskornStanga2012-2] Jump up to: ^a ^b Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7.

[pmid9098663-3] Jump up to: ^a ^b Davis R, Whittington R, Bryson HM (1997). "Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression". Drugs. 53 (4): 608–36. doi:10.2165/00003495-199753040-00006. PMID 9098663.

[1]

[2]

[3]

Hydroxynefazodone

See also[]

References[]