Inositol-1,4-bisphosphate 1-phosphatase

In enzymology, an inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) is an enzyme that catalyzes the chemical reaction

1D-myo-inositol 1,4-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1D-myo-inositol 4-phosphate + phosphate

Thus, the two substrates of this enzyme are and H₂O, whereas its two products are and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and .

Structural studies[]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.

References[]

• Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
• Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. PMID 3029066.
• Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. PMID 2824473.