Phosphatidylinositol-3,4-bisphosphate 4-phosphatase

In enzymology, a phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

Thus, the two substrates of this enzyme are and H₂O, whereas its two products are and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase. Other names in common use include inositol-3,4-bisphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, phosphoinositide 4-phosphatase, inositol polyphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, and inositol polyphosphate 4-phosphatase type II. This enzyme participates in inositol phosphate metabolism and .

References[]

• Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS (1989). "Evidence for at least four different inositol bisphosphatases in bovine brain". Eur. J. Biochem. 183 (1): 169–72. doi:10.1111/j.1432-1033.1989.tb14909.x. PMID 2546770.
• Norris FA, Auethavekiat V, Majerus PW (1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J. Biol. Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
• Norris FA, Atkins RC, Majerus PW (1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J. Biol. Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.