Trans-2-decenoyl-(acyl-carrier protein) isomerase

In enzymology, a trans-2-decenoyl-[acyl-carrier protein] isomerase (EC 5.3.3.14) is an enzyme that catalyzes the chemical reaction

trans-dec-2-enoyl-[acyl-carrier-protein] ${\displaystyle \rightleftharpoons }$ cis-dec-3-enoyl-[acyl-carrier-protein]

Hence, this enzyme has one substrate, [[trans-dec-2-enoyl-[acyl-carrier-protein]]], and one product, [[cis-dec-3-enoyl-[acyl-carrier-protein]]].

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase. Other names in common use include beta-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, and FabM.

References[]

• Brock DJ, Kass LR, Bloch K (1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–40. PMID 4863740.
• Bloch K (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2 (7): 193–202. doi:10.1021/ar50019a001.
• Marrakchi H, Choi KH, Rock CO (2002). "A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae". J. Biol. Chem. 277 (47): 44809–16. doi:10.1074/jbc.M208920200. PMID 12237320.
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.