Arctiin
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IUPAC name
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-{[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl}oxolan-2-one
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3D model (JSmol)
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ChEMBL | |
ChemSpider | |
MeSH | arctigenin |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
Chemical formula
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C27H34O11 |
Molar mass | 534.558 g·mol−1 |
Melting point | 110 to 112 °C (230 to 234 °F; 383 to 385 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Arctiin is a lignan found in many plants of the family Asteraceae, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla,[1] and Forsythia viridissima.[2] It is the glucoside of arctigenin.
Arctiin and arctigenin have shown anticancer effects in animal research.[citation needed] They have been found to act as agonists of the adiponectin receptor 1.[3]
References[]
- ^ Arvind Saklani; Manas Ranjan Sahoo; Prabhu Dutt Mishra; Ram Vishwakarma (2010). "Saussurea heteromalla (D. Don) Hand.-Mazz.: A new source of arctiin, arctigenin and chlorojanerin" (PDF). Indian Journal of Chemistry. India: NISCAIR-CSIR. 50B: 624. ISSN 0975-0983. Retrieved on April 25, 2011.
- ^ David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. p. 172. ISBN 0-412-46630-9. Retrieved on September 14, 2008 through Google Book Search.
- ^ Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.
External links[]
- Arctiin entry in the public domain NCI Dictionary of Cancer Terms
This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".
Categories:
- Adiponectin receptor agonists
- Lignan glucosides
- O-Methylated natural phenols
- Lactones
- Aromatic compound stubs