From Wikipedia, the free encyclopedia
The gonadotropin receptors are a group of receptors that bind a group of pituitary hormones called gonadotropins. They include the:
- Follicle-stimulating hormone receptor (FSHR) - binds follicle-stimulating hormone (FSH)
- Luteinizing hormone receptor (LHR) - binds luteinizing hormone (LH) and human chorionic gonadotropin (hCG)
See also[]
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G protein-coupled receptor | Hormone receptors | Hypothalamic | |
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Pituitary | |
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Other | |
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Opioid receptors | |
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Other neuropeptide receptors | |
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Type I cytokine receptor | |
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Enzyme-linked receptor | |
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Other | |
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Cell surface receptor: G protein-coupled receptors |
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Neurotransmitter | Adrenergic |
- α1 (A
- B
- D)
- α2 (A
- B
- C)
- β1
- β2
- β3
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Purinergic |
- Adenosine (A1
- A2A
- A2B
- A3)
- P2Y (1
- 2
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14)
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Serotonin | |
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Other |
- Acetylcholine (M1
- M2
- M3
- M4
- M5)
- Dopamine
- GHB receptor
- Histamine
- Melatonin (1A
- 1B
- 1C)
- TAAR (1
- 2
- 5
- 6
- 8
- 9)
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Metabolites and signaling molecules | Eicosanoid |
- CysLT (1
- 2)
- LTB4
- FPRL1
- OXE
- Prostaglandin
- DP (1
- 2), EP (1
- 2
- 3
- 4), FP
- Prostacyclin
- Thromboxane
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Other |
- Bile acid
- Cannabinoid (CB1
- CB2, GPR (18
- 55
- 119))
- EBI2
- Estrogen
- Free fatty acid (1
- 2
- 3
- 4)
- Hydroxycarboxylic acids
- Lysophosphatidic acid (1
- 2
- 3
- 4
- 5
- 6)
- Lysophospholipid (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8)
- Oxoglutarate
- PAF
- Sphingosine-1-phosphate (1
- 2
- 3
- 4
- 5)
- Succinate
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Peptide | |
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Miscellaneous | |
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Taste, sweet | |
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Other |
- Calcium-sensing receptor
- GABAB (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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GnRH modulators (incl. analogues) | Agonists |
- Peptide: Azagly-nafarelin
- Buserelin
- Deslorelin
- Fertirelin
- Gonadorelin
- Goserelin
- Histrelin
- Lecirelin
- Leuprorelin (leuprolide)
- Nafarelin
- Peforelin
- Triptorelin
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Antagonists |
- Peptide: Abarelix
- Cetrorelix
- Degarelix
- Ganirelix
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Gonadotropins | Preparations |
- Follicle-stimulating hormone
- Human chorionic gonadotropin
- Luteinizing hormone
- Menotropin
- Urofollitropin
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Others (indirect) | Progonadotropins |
- Sex steroid antagonists (via disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide)
- Antiestrogens/SERMs (e.g., tamoxifen, clomifene, enclomifene)
- Aromatase inhibitors (e.g., anastrozole)
- GnRH agonists (e.g., GnRH)
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Antigonadotropins |
- Sex steroid agonists (via negative feedback on the HPG axis): Androgens/anabolic steroids (e.g., testosterone, nandrolone esters, oxandrolone)
- D2 receptor antagonists (prolactin releasers) (incl., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)
- Estrogens (incl., bifluranol, estradiol, estradiol esters, ethinylestradiol, diethylstilbestrol, paroxypropione)
- Progestogens (incl. progestins, e.g., chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate)
- Others (mixed or unknown mechanism of action): Danazol
- Gestrinone
- Metallibure
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- GnRH and gonadotropin receptor modulators
- Androgens and antiandrogens
- Estrogens and antiestrogens
- Progestogens and antiprogestogens
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Categories:
- G protein-coupled receptors
- Gonadotropin-releasing hormone and gonadotropins
- Signal transduction
- Cell signaling
- Transmembrane receptor stubs