Galanin receptor 3

GALR3
Identifiers
Aliases	GALR3, Galanin receptor 3
External IDs	OMIM: 603692 MGI: 1329003 HomoloGene: 20798 GeneCards: GALR3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,823,382 bp[1] End 37,825,485 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.7 cM Start 79,041,885 bp[2] End 79,043,558 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • galanin receptor activity • G protein-coupled receptor activity • signal transducer activity • peptide hormone binding • G protein-coupled peptide receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane • non-motile cilium • cilium Biological process • learning or memory • phospholipase C-activating G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • feeding behavior • positive regulation of transcription by RNA polymerase II • signal transduction • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • chemical synaptic transmission • G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of adenylate cyclase activity • galanin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8484	14429
Ensembl	ENSG00000128310	ENSMUSG00000114755
UniProt	O60755	O88853
RefSeq (mRNA)	NM_003614	NM_015738
RefSeq (protein)	NP_003605	NP_056553
Location (UCSC)	Chr 22: 37.82 – 37.83 Mb	Chr 15: 79.04 – 79.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Galanin receptor 3 (GAL₃) is a G-protein coupled receptor encoded by the GALR3 gene.^[5]

Function[]

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts^[5]

See also[]

• Galanin receptor

References[]

Further reading[]

External links[]

• "Galanin Receptors: GAL₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.