Benperidol
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| Trade names | Anquil, Frenactil |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Identifiers | |
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| ECHA InfoCard | 100.016.521  |
| Chemical and physical data | |
| Formula | C22H24FN3O2 |
| Molar mass | 381.451 g·mol−1 |
| 3D model (JSmol) | |
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Benperidol, sold under the trade name Anquil[1] among others, is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[2] It is an antipsychotic, which can be used for the treatment of schizophrenia,[3] but it is primarily used to control hypersexuality syndromes[4] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[5]
Benperidol was discovered at Janssen Pharmaceutica in 1961.
Synthesis[]
Benperidol synthesis:[6]
See also[]
- Timiperone has the same structure but thiourea instead of normal urea.
- Pimozide & Bezitramide (& & ) are also made from 4-(1-Benzimidazolinone)piperidine precursor
- Droperidol is self-same albeit with a tetrahydropyridine ring.
References[]
- ^ Council A, Kuenssberg V (1974-02-01). "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. BMJ Publishing Group Ltd. 12: 12.
- ^ Möller HJ, Müller WE, Bandelow (2001). Neuroleptika: pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen; mit 136 Tabellen (in German). Wiss. Verlag-Ges. ISBN 3-8047-1773-X.
- ^ Bobon J, Collard J, Lecoq R (October 1963). "[Benperidol and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica Et Psychiatrica Belgica (in French). 63: 839–43. PMID 14092279.
- ^ British National Formulary (49th), British Medical Association 2005 p 183
- ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ (November 1975). "Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers". The Journal of Endocrinology. 67 (2): 179–88. doi:10.1677/joe.0.0670179. PMID 1107462.
- ^ BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.
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Categories:
- Belgian inventions
- Benzimidazoles
- Butyrophenone antipsychotics
- Janssen Pharmaceutica
- Fluoroarenes
- Piperidines
- Typical antipsychotics
- Nervous system drug stubs