Dufferin—Simcoe was a federal electoral district represented in the House of Commons of Canada from 1925 to 1968. It was located in the province of Ontario. This riding was created in 1924 from parts of Dufferin and Simcoe Southridings.
It initially consisted of the county of Dufferin and that part of the county of Simcoe lying south of and including the townships of Tossorontio, Essa and Innisfil. In 1933, it was redefined to exclude the townships of East Luther and East Garafraxa in the county of Dufferin, and no part of the town of Barrie.
In 1947, it was defined as consisting of the county of Dufferin, including the town of Orangeville, but excluding the townships of East Luther and East Garafraxa, and the part of the county of Simcoe lying south of and including the townships of Tosorontio, Essa and Innisfil, and excluding the town of Barrie.
In 1952, it was defined as consisting of the county of Dufferin and the town of Orangeville, and the part of the county of Simcoe lying south of and including the townships of Tosorontio, Essa and Innisfil (excluding the town of Barrie).