HES5

HES5
Identifiers
Aliases	HES5, bHLHb38, hes family bHLH transcription factor 5
External IDs	OMIM: 607348 MGI: 104876 HomoloGene: 7755 GeneCards: HES5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,530,263 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	154,962,371 bp
Gene ontology
Molecular function	• DNA binding; • protein dimerization activity; • transcription factor binding; • chromatin binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • double-stranded DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Cellular component	• nucleoplasm; • nucleus; • cellular component;
Biological process	• Notch signaling pathway; • auditory receptor cell fate determination; • establishment of epithelial cell polarity; • cell differentiation; • negative regulation of astrocyte differentiation; • regulation of inner ear auditory receptor cell differentiation; • regulation of transcription, DNA-templated; • negative regulation of neuron differentiation; • inner ear receptor cell stereocilium organization; • comma-shaped body morphogenesis; • metanephric nephron tubule morphogenesis; • chondrocyte differentiation; • central nervous system myelination; • negative regulation of transcription by RNA polymerase II; • cell maturation; • negative regulation of forebrain neuron differentiation; • transcription, DNA-templated; • nervous system development; • negative regulation of stem cell differentiation; • neuronal stem cell population maintenance; • positive regulation of transcription, DNA-templated; • multicellular organism development; • glial cell fate commitment; • telencephalon development; • brain development; • inner ear auditory receptor cell differentiation; • cell adhesion; • astrocyte differentiation; • cartilage development; • forebrain radial glial cell differentiation; • regulation of myelination; • negative regulation of oligodendrocyte differentiation; • S-shaped body morphogenesis; • neural tube development; • neuron differentiation; • positive regulation of cell population proliferation; • positive regulation of BMP signaling pathway; • negative regulation of pro-B cell differentiation; • regulation of cell differentiation; • smoothened signaling pathway; • oligodendrocyte development; • camera-type eye development; • specification of loop of Henle identity; • regulation of epithelial cell proliferation; • negative regulation of transcription, DNA-templated; • negative regulation of inner ear receptor cell differentiation; • regulation of neurogenesis; • positive regulation of receptor signaling pathway via JAK-STAT; • positive regulation of Notch signaling pathway; • positive regulation of transcription by RNA polymerase II; • positive regulation of smooth muscle cell proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • protein-containing complex assembly; • somitogenesis; • central nervous system development; • anterior/posterior pattern specification; • negative regulation of inner ear auditory receptor cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	388585
	15208
	ENSG00000273529; ENSG00000197921
	ENSMUSG00000048001
	Q5TA89
	P70120
	NM_001010926
	NM_010419; NM_001370755
	NP_001010926
	NP_034549; NP_001357684
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.^[5]^[6]

HES5 regulates brain development process.^[7] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.^[8] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.^[9]

References[]

^ ^a ^b ^c ENSG00000197921 GRCh38: Ensembl release 89: ENSG00000273529, ENSG00000197921 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048001 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401.
^ "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".
^ Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443.
^ Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. S2CID 25609083.
^ Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726.

External links[]

HES5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000197921 GRCh38: Ensembl release 89: ENSG00000273529, ENSG00000197921 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048001 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7836401-5] Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401.

[entrez-6] "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".

[pmid15496443-7] Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443.

[pmid17388915-8] Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. S2CID 25609083.

[pmid17093926-9] Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726.

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HES5

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