HOXC6

HOXC6
Identifiers
Aliases	HOXC6, CP25, HHO.C8, HOX3, HOX3C, homeobox C6
External IDs	OMIM: 142972 MGI: 96197 HomoloGene: 19533 GeneCards: HOXC6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,030,823 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,011,881 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; ovary; ; renal medulla; ; Germinal epithelium; ; renal cortex; ; embryo; ; corpus epididymis; ; nipple;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; GO:0001106 transcription corepressor activity; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; anterior/posterior pattern specification; embryonic skeletal system development; negative regulation of nucleic acid-templated transcription; multicellular organism development; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3223
	15425
	ENSG00000197757
	ENSMUSG00000001661
	P09630
	P10629
	NM_153693; NM_004503
	NM_010465
	NP_004494; NP_710160
	NP_034595
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene.^[5]^[6]^[7]

Function[]

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197757 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001661 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ ^a ^b "Entrez Gene: HOXC6 homeobox C6".

Further reading[]

Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. Bibcode:1986PNAS...83.9104R. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (Jul 1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proceedings of the National Academy of Sciences of the United States of America. 84 (14): 4914–8. Bibcode:1987PNAS...84.4914S. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844.
Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E (Jun 1988). "At least three human homeoboxes on chromosome 12 belong to the same transcription unit". Nucleic Acids Research. 16 (12): 5379–90. doi:10.1093/nar/16.12.5379. PMC 336773. PMID 2898768.
Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G (Jan 1995). "Nucleolar localisation of three Hox homeoproteins". Journal of Cell Science. 108 ( Pt 1) (1): 187–93. doi:10.1242/jcs.108.1.187. PMID 7738096.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Chariot A, Castronovo V, Le P, Gillet C, Sobel ME, Gielen J (Oct 1996). "Cloning and expression of a new HOXC6 transcript encoding a repressing protein". The Biochemical Journal. 319 ( Pt 1) (1): 91–7. doi:10.1042/bj3190091. PMC 1217739. PMID 8870653.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Ramachandran S, Liu P, Young AN, Yin-Goen Q, Lim SD, Laycock N, Amin MB, Carney JK, Marshall FF, Petros JA, Moreno CS (Jan 2005). "Loss of HOXC6 expression induces apoptosis in prostate cancer cells". Oncogene. 24 (1): 188–98. doi:10.1038/sj.onc.1207906. PMID 15637592.
Hori Y, Gu X, Xie X, Kim SK (Apr 2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Medicine. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Zhang X, Hamada J, Nishimoto A, Takahashi Y, Murai T, Tada M, Moriuchi T (2007). "HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells". Journal of Cellular and Molecular Medicine. 11 (2): 299–306. doi:10.1111/j.1582-4934.2007.00020.x. PMC 3822828. PMID 17488478.