HOXC9

HOXC9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LP0, 2MSY
Identifiers
Aliases	HOXC9, HOX3, HOX3B, homeobox C9
External IDs	OMIM: 142971 MGI: 96199 HomoloGene: 130558 GeneCards: HOXC9
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,003,337 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,985,099 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • GO:0001948 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• nucleus; • nucleoplasm; • aggresome;
Biological process	• embryonic skeletal system morphogenesis; • multicellular organism development; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • anterior/posterior pattern specification; • embryonic skeletal system development; • regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3225
	15427
	ENSG00000180806
	ENSMUSG00000036139
	P31274
	P09633
	NM_006897
	NM_008272
	NP_008828
	NP_032298
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.^[5]^[6]

Function[]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180806 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036139 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ ^a ^b "Entrez Gene: HOXC9 homeobox C9".

Further reading[]

Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (December 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. Bibcode:1986PNAS...83.9104R. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
Redline RW, Hudock P, MacFee M, Patterson P (November 1994). "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology. 71 (5): 663–70. PMID 7967520.
Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (January 1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 900–5. Bibcode:1996PNAS...93..900M. doi:10.1073/pnas.93.2.900. PMC 40155. PMID 8570656.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (October 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979. S2CID 26075369.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (February 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature. 427 (6976): 749–53. Bibcode:2004Natur.427..749L. doi:10.1038/nature02305. hdl:11858/00-001M-0000-0012-EE32-1. PMID 14973489. S2CID 8020382.
Okamoto OK, Oba-Shinjo SM, Lopes L, Nagahashi Marie SK (2007). "Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (7–8): 437–42. doi:10.1016/j.bbaexp.2007.05.002. PMID 17588684.

External links[]

HOXC9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P31274 (Homeobox protein Hox-C9) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180806 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036139 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-6] "Entrez Gene: HOXC9 homeobox C9".

[1]

[2]

[3]

[4]

[5]

[6]

HOXC9

Contents

Function[]

See also[]

References[]

Further reading[]

External links[]