NFE2

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NFE2
Protein NFE2 PDB 1LVX.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDsOMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCards: NFE2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

NP_001129495
NP_001248390
NP_006154

Location (UCSC)Chr 12: 54.29 – 54.3 MbChr 15: 103.25 – 103.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.[5][6]

It is involved in megakaryocyte production.[7]

Interactions[]

NFE2 has been shown to interact with CREB-binding protein.[8]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123405 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058794 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC 360284. PMID 8355703.
  6. ^ "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
  7. ^ Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMID 25721735. S2CID 18020988.
  8. ^ Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

Further reading[]

External links[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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