OLIG1

OLIG1
Identifiers
Aliases	OLIG1, BHLHB6, BHLHE21, oligodendrocyte transcription factor 1
External IDs	OMIM: 606385 MGI: 1355334 HomoloGene: 9667 GeneCards: OLIG1
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,072,413 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,271,933 bp
RNA expression pattern
	Top expressed in
	subthalamic nucleus; ; substantia nigra; ; inferior ganglion of vagus nerve; ; amygdala; ; hypothalamus; ; internal globus pallidus; ; corpus callosum;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; GO:0001948 protein binding; protein dimerization activity; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; neuron fate commitment; oligodendrocyte differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	116448
	50914
	ENSG00000184221
	ENSMUSG00000046160
	Q8TAK6
	Q9JKN5
	NM_138983
	NM_016968
	NP_620450
	NP_058664
	Wikidata
View/Edit Human	View/Edit Mouse

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184221 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046160 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (19): 10851–6. Bibcode:2001PNAS...9810851L. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205.
^ "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1".

Further reading[]

Zhou Q, Wang S, Anderson DJ (Feb 2000). "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 (2): 331–43. doi:10.1016/S0896-6273(00)80898-3. PMID 10719889. S2CID 16560063.
Takebayashi H, Yoshida S, Sugimori M, Kosako H, Kominami R, Nakafuku M, Nabeshima Y (Dec 2000). "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3". Mechanisms of Development. 99 (1–2): 143–8. doi:10.1016/S0925-4773(00)00466-4. PMID 11091082. S2CID 1472243.
McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Gene Expression Patterns. 2 (3–4): 329–35. doi:10.1016/S0925-4773(02)00390-8. PMID 12617822.
McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Mechanisms of Development. 119 Suppl 1: S285-91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. S2CID 5903576.
Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (Dec 2004). "bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS". Science. 306 (5704): 2111–5. Bibcode:2004Sci...306.2111A. doi:10.1126/science.1103709. PMID 15604411. S2CID 31228720.
Jakovcevski I, Zecevic N (Nov 2005). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS". The Journal of Neuroscience. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMC 6725798. PMID 16267213.
Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S (Nov 2006). "Novel Olig 1-coding variants and susceptibility to multiple sclerosis". Journal of Neurology, Neurosurgery, and Psychiatry. 77 (11): 1296–7. doi:10.1136/jnnp.2006.090639. PMC 2077377. PMID 16820418.
Ruf N, Martelli M, Weschke B, Uhlenberg B (Apr 2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy". American Journal of Medical Genetics Part B. 144B (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653. S2CID 25663863.
Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C (Mar 2007). "Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer". PLOS Medicine. 4 (3): e108. doi:10.1371/journal.pmed.0040108. PMC 1831740. PMID 17388669.

External links[]

OLIG1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184221 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046160 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11526205-5] Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (19): 10851–6. Bibcode:2001PNAS...9810851L. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205.

[entrez-6] "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1".

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