Pyrethrin I

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Pyrethrin I
Pyrethrin-I-2D-skeletal.svg
Names
Preferred IUPAC name
(1S)-2-Methyl-4-oxo-3-[(2Z)-penta-2,4-dien-1-yl]cyclopent-2-en-1-yl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.004.051 Edit this at Wikidata
EC Number
  • 204-455-8
KEGG
UNII
Properties
C21H28O3
Molar mass 328.44522
Hazards
GHS pictograms GHS07: HarmfulGHS09: Environmental hazard
GHS Signal word Warning
GHS hazard statements
 H302, H312, H332, H400, H410
P261, P264, P270, P271, P273, P280, P301+312, P302+352, P304+312, P304+340, P312, P322, P330, P363, P391, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pyrethrin I is one of the two pyrethrins, natural organic compounds with potent insecticidal activity. It is an ester of (+)-trans-chrysanthemic acid with (S)-(Z)-.

Total synthesis[]

The synthesis of pyrethrin I involves the esterification of (+)-trans-chrysanthemic acid with (S)-(Z)-pyrethrolone. One synthetic method for each of these is shown in the images below. Sobti and Dev of the Malti-Chem Research Centre in Nadesari, vadodara, India published this method for chrysanthemic acid in 1974. The starting material for the synthesis uses commercially available (+)-3α, 4α-epoxycarane (1). A lactone is eventually formed and the ring is opened by the use of a Grignard reagent to give (+)-trans-chrysanthemic acid. [1] The preparation of (S)-pyrethrolone is essentially a 2 step synthesis. The starting material (S)-4-hydroxy-3-methyl-2-(2-propynyl)-2-cyclopenten-1-one (7) is also commercially available as the alcohol moiety of ETOC. Tetrakis(triphenylphosphine)palladium(0), copper(I) iodide, triethylamine, and vinyl bromide are added to (7) to add two more carbons and form (8). The final step is the addition of an activated zinc compound to reduce the triple carbon bond to form the cis product, (S)-pyrethrolone (9). [2] Although no journal articles specify the combining of the alcohol and acid moieties of pyrethrin I, they could be combined through an esterification process to form the wanted product.

Synthesis of the acid moiety[]

Pyrethrinfigure2.gif

Synthesis of the alcohol moiety[]

Pyrethrinfigure1.gif

References[]

  1. ^ Sobti, R., Dev, S. (1974). "(+)-TRANS-CHRYSANTHEMIC ACID FROM (+)-Δ3-Carene". Tetrahedron. 30 (16): 2927–2929. doi:10.1016/S0040-4020(01)97467-8.CS1 maint: multiple names: authors list (link)
  2. ^ Matsuo, N., Takagaki, T., Watanabe, K., Ohno, N. (1993). "The First Practical Synthesis of (S)-Pyrethrolone, an Alcohol Moiety of Natural Pyrethrins I and II". Biosci. Biotechnol. Biochem. 57 (4): 693–694. doi:10.1271/bbb.57.693.CS1 maint: multiple names: authors list (link)
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