Selenophos

Selenophos^[1]
Names

Preferred IUPAC name Se-[2-(Diethylamino)ethyl] O-ethyl ethylphosphonoselenoate
Identifiers
CAS Number	10161-84-9
3D model (JSmol)	Interactive image
ChemSpider	175244
PubChem CID	202353
CompTox Dashboard (EPA)	DTXSID00906396
InChI InChI=1S/C10H24NO2PSe/c1-5-11(6-2)9-10-15-14(12,8-4)13-7-3/h5-10H2,1-4H3 Key: QNGZOSUHNXJPIY-UHFFFAOYSA-N
SMILES CCN(CC)CC[Se]P(=O)(CC)OCC
Properties
Chemical formula	C₁₀H₂₄NO₂PSe
Molar mass	300.252 g·mol⁻¹
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	21 μg/kg (mouse, subcutaneous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Selenophos is an extremely potent organophosphate acetylcholinesterase inhibitor.^[2] It is the selenium analog of the VE nerve agent.

References[]

^ Nachmansohn, David (1 July 1969). "Proteins of Excitable Membranes". The Journal of General Physiology. 54 (1): 187–224. doi:10.1085/jgp.54.1.187. PMC 2225914. PMID 19873642.
^ Akerfeldt, Stig.; Fagerlind, Lars. (January 1967). "Selenophosphorus Compounds as Powerful Cholinesterase Inhibitors". Journal of Medicinal Chemistry. 10 (1): 115–116. doi:10.1021/jm00313a032. PMID 6031689.

Acetylcholine metabolism and transport modulators

Enzyme
(modulators)

ChAT	Inhibitors:
AChE	Inhibitors: Reversible: Carbamates: Aldicarb Aminocarb Bendiocarb Carbaryl Carbendazim Carbofuran Carbosulfan Dimetilan Ethienocarb Ethiofencarb Fenobucarb Formetanate Formparanate Methiocarb Methomyl Metolcarb Miotine Oxamyl Pirimicarb Promecarb Propamocarb Propoxur Thiofanox; Stigmines: Distigmine Neostigmine Phenserine Physostigmine Pyridostigmine Rivastigmine ; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine X Ipidacrine Itopride Ladostigil Minaprine Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide) T-1123 TL-599 TL-1238 Tacrine Irreversible: Organophosphates: 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate Acephate Armine Azinphos-ethyl Azinphos-methyl BAY-29952 Bensulide Carbophenothion Chlorethoxyfos Chlorfenvinphos Chlorpyrifos Coumaphos Crotylsarin Cyanophos Cyclosarin (GF) Demephion Demeton Demeton-S-methyl Dialifor Diazinon Dichlorvos Dicrotophos Diisopropylphosphate Dimefox Dimethoate Dimethyl 4-(methylthio)phenyl phosphate Dioxathion Disulfoton EA-2012 EA-2054 EA-2098 EA-2192 EA-2613 EA-3148 EA-4352 Echothiophate Ethylsarin (GE) Endothion EPN Ethion Ethoprop Fenamiphos Fenitrothion Fenthion Fluorotabun Fonofos Formothion GD-42 GH GV Guanitoxin Hexaethyl tetraphosphate (HETP) Isofluorophate Isoxathion Leptophos Malaoxon Malathion Methamidophos Methidathion Methyl phenkapton Methylfluorophosphonylcholine (MFPCh) Metrifonate Mevinphos Mipafox Monocrotophos Naled Novichok agent Omethoate Oxydemeton-methyl Paraoxon Parathion Parathion-methyl Phorate Phosalone Phosfolan Phosmet Phosphamidon Phoxim Pirimiphos-methyl Profenofos Prothoate R-16661 Ro 3-0412 Ro 3-0419 Ro 3-0422 Sarin (GB) Schradan Soman (GD) Sulfotep (TEDP) Tabun (GA) Tebupirimfos Temefos Terbufos Tetrachlorvinphos Tetraethyl pyrophosphate (TEPP) Triazofos Trichlorfon Trichloronate Tricresyl phosphate VE VG VM VP VS VR VX; Others: Demecarium Fasciculins (green mamba toxins) (, , , ) Onchidal (Onchidella binneyi) Methanesulfonyl fluoride Unsorted: α-Pinene α-Viniferin Affinine Affinisine Arisugacin A Bulbocapnine Conodurine Coronaridine Corydaline Corynoline Crimidine Cyclanoline Cymserine Harmaline Kobophenol A Lactucopicrin Lycorine Phosacetim Rosmarinic acid Stercuronium iodide Taspine Tetrahydrocannabinol Ungeremine Ungiminorine Dimethylcarbamoyl fluoride BW284C51 TMTFA Reactivators: Asoxime chloride Obidoxime Pralidoxime Trimedoxime bromide
BChE	Inhibitors: Affinine Affinisine Conodurine Cymserine Ladostigil Profenamine (ethopropazine) Rivastigmine Tacrine Many of the other AChE inhibitors listed above

Transporter
(modulators)

CHT	Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine Enhancers: Coluracetam
VAChT	Inhibitors: Vesamicol

Release
(modulators)

Inhibitors	SNAP-25 inactivators: Botulinum toxin (A, , ) VAMP inactivators: Botulinum toxin (, , , ) Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)
Enhancers	LPHN agonists: α-Latrotoxin Others: Atracotoxins (e.g., robustoxin, versutoxin) Crotoxin

See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators

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Selenophos

See also[]

References[]