Sulpiride

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Sulpiride
Sulpiride.svg
Sulpiride ball-and-stick.png
Clinical data
Trade namesDogmatil, others
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth (tablets, capsules, solution), intramuscular injection
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability25–40%[1][2]
Protein binding<40%[1]
MetabolismNot metabolized[3][4][5][6][7]
Elimination half-life6–8 hours[1]
ExcretionUrine (70–90%)[2]
Feces (~95% as the unchanged drug)[1]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.036.124 Edit this at Wikidata
Chemical and physical data
FormulaC15H23N3O4S
Molar mass341.43 g·mol−1
3D model (JSmol)
InChI
  

Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic)[8] medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose. It is not approved in the United States, Canada, or Australia. The drug is chemically and clinically similar to amisulpride.

Medical uses[]

Sulpiride's primary use in medicine is in the management of the symptoms of schizophrenia.[1] It has been used as both a monotherapy and adjunctive therapy (in case of treatment-resistance) in schizophrenia.[1][9][10][11][12][13] It has also been used in the treatment of dysthymia.[14] There is evidence, although low quality, that Sulpiride could accelerate antidepressant response in patients with major depressive disorder.[15] There is also evidence of its efficacy in treating panic disorder.[16][17] Sulpiride is indicated for the treatment of vertigo in some countries.[18] In Japan, Sulpiride is both approved as a treatment for schizophrenia and for major depressive disorder (low dose).[19][20]

Contraindications[]

Contraindications[1]

  • Hypersensitivity to sulpiride
  • Pre-existing breast cancer or other prolactin-dependent tumors
  • Phaeochromocytoma
  • Intoxication with other centrally-active drugs
  • Concomitant use of levodopa
  • Acute porphyria
  • Comatose state or CNS depression
  • Bone-marrow suppression

Cautions[1]

  • Pre-existing Parkinson's disease
  • Patients under 18 years of age (insufficient clinical data)
  • Pre-existing severe heart disease/bradycardia, or hypokalemia (predisposing to long QT syndrome and severe arrhythmias)
  • Patients with pre-existing epilepsy. Anticonvulsant therapy should be maintained
  • Lithium use — increased risk of neurological side effects of both drugs

Pregnancy and lactation[]

  • Pregnancy: Animal studies did not reveal any embryotoxicity or fetotoxicity, nor did limited human experience. Due to insufficient human data, pregnant women should be treated with sulpiride only if strictly indicated. Additionally, the newborns of treated women should be monitored, because isolated cases of extrapyramidal side effects have been reported.[1]
  • Lactation: Sulpiride is found in the milk of lactating women. Since the consequences are unclear, women should not breastfeed during treatment.[1]

Side effects[]

Sulpiride is usually well tolerated, producing few adverse effects. Their incidences are as follows:[1][9][21][22][23][24][25][26][27]

Common (>1%) adverse effects
  • Dizziness
  • Headache
  • Extrapyramidal side effects
- Tremor
- Dystonia
- Akathisia — a sense of inner restlessness that presents itself with the inability to stay still
- Parkinsonism
  • Somnolence (not a very prominent adverse effect considering its lack of α1 adrenergic, histamine and muscarinic acetylcholine receptor affinity)
  • Insomnia
  • Weight gain or loss
  • Hyperprolactinemia (elevated plasma levels of the hormone, prolactin which can, in turn lead to sexual dysfunction, galactorrhea, amenorrhea, gynecomastia, etc.)
  • Nausea
  • Vomiting
  • Nasal congestion
  • Anticholinergic adverse effects such as:
- Dry mouth
- Constipation
- Blurred vision
  • Impaired concentration
Rare (<1% incidence) adverse effects
  • Tardive dyskinesia — a rare, often permanent movement disorder that, more often than not, results from prolonged treatment with antidopaminergic agents such as antipsychotics. It presents with slow (hence tardive), involuntary, repetitive and purposeless movements that most often affect the facial muscles.
  • Neuroleptic malignant syndrome — a rare, life-threatening complication that results from the use of antidopaminergic agents. Its incidence increases with concomitant use of lithium (medication) salts
  • Blood dyscrasias — rare, sometimes life-threatening complications of the use of a number of different antipsychotics (most notably clozapine) which involves abnormalities in the composition of a person's blood (e.g. having too few white blood cells per unit volume of blood). Examples include:
- Agranulocytosis — a significant drop in white blood cell count, leaving individuals wide open to life-threatening opportunistic infections
- Neutropenia
- Leucopenia
- Leukocytosis[28]
  • Seizures
  • Torsades de pointes
Unknown incidence adverse effects include
  • QTc interval prolongation which can lead to potentially fatal arrhythmias.
  • Cholestatic jaundice[29]
  • Elevated liver enzymes
  • Primary biliary cirrhosis[30]
  • Allergic reactions
  • Photosensitivity — sensitivity to light
  • Skin rashes
  • Depression
  • Catatonia
  • Palpitations
  • Agitation
  • Diaphoresis — sweating without a precipitating factor (e.g. increased ambient temperature)
  • Hypotension — low blood pressure
  • Hypertension — high blood pressure
  • Venous thromboembolism (probably rare)

Overdose[]

Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trismus. In some cases all the classical symptoms typical of severe Parkinson's disease may be noted; in others, over-sedation/coma may occur. The treatment is largely symptomatic. Some or all extrapyramidal reactions may respond to the application of anticholinergic drugs such as biperiden or benzatropine. All patients should be closely monitored for signs of long QT syndrome and severe arrhythmias.

Interactions[]

Sulpiride neither inhibits nor stimulates cytochrome P450 family (CYP) of oxidizing enzymes in human, thus would not cause clinically significant interactions with other drugs,[4] which are metabolized by CYPs. However, the risk or severity of adverse effects can be increased when sulpiride is combined with other drugs, but this is not related to substrates, inducers and inhibitors of CYPs.

Pharmacology[]

Pharmacodynamics[]

Sulpiride[31]
Receptor Affinity (Ki, nM)
DAT >10,000
5-HT1A >10,000
5-HT2A 4,786
5-HT3 >10,000
5-HT6 5,011[unreliable source?]
5-HT7 5,011[unreliable source?]
α1 >10,000
α2 >10,000
D1 >10,000
D2 9.8
D3 8.05
D4 54
H1 >10,000
V3 >10,000
Affinity values are toward cloned human receptors.

Sulpiride is a selective antagonist at dopamine D2, D3 and 5-HT1A receptors. Antagonism at 5-HT1A dominates in doses exceeding 600 mg daily. In doses of 600 to 1,600 mg sulpiride shows mild sedating and antipsychotic activity. Its antipsychotic potency compared to chlorpromazine is only 0.2 (1/5). In low doses (in particular 50 to 200 mg daily) its prominent feature is antagonism of presynaptic inhibitory dopamine and serotonin receptors, accounting for some antidepressant activity and a stimulating effect. Additionally, it alleviates vertigo.

The benzamide neuroleptics (including sulpiride, amisulpride, and sultopride) have been shown to activate the endogenous gamma-hydroxybutyrate receptor in vivo at therapeutic concentrations.[32] Sulpiride was found in one study in rats to upregulate GHB receptors.[33] GHB has neuroleptic properties and it is believed binding to this receptor may contribute to the effects of these neuroleptics.

Sulpiride, along with clozapine, has been found to activate DNA demethylation in the brain.[34]

Chemistry[]

Synthesis[]

Sulpiride synthesis: E.L. Engelhardt, Ch.S. Miller, DE 1595915  (1965) E.L. Engelhardt, Ch.S. Miller, DE 1795723  (1965) E.L. Engelhardt, M.L. Thominet, U.S. Patent 3,342,826 (1969) G. Bulteau, J. Acher, U.S. Patent 4,077,976 (1978) F. Mauri, DE 2903891  (1979).

Sulpiride can be synthesized from 5-aminosulfosalicylic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid, which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as the amine component and carbonyldiimidazole (CDI) as a condensing agent.

History[]

Sulpiride was discovered as a result of a research program by Justin-Besançon and C. Laville at Laboratoires Delagrange who were working to improve the anti-dysrhythmic properties of procainamide; the program led first to metoclopramide and later to sulpiride.[35][36] Laboratoires Delagrange was acquired by Synthelabo in 1991[37][38] which eventually became part of Sanofi.[39]

Society and culture[]

Brand names[]

Sulpiride is marketed under the brand names Dogmatil (DE, HK, SG, PH), Dolmatil (IE, UK), Eglonyl (RU, ZA), Espiride (ZA), Modal (IL), Prometar (UY), and Sulpor (UK), among many others.[40]

Medicinal forms[]

These include tablet and oral solution[41]

Research[]

Sulpiride has been studied for use as a hormonal contraceptive in women in whom conventional oral contraceptives are contraindicated and to potentiate progestogen-only contraceptives.[42][43] The contraceptive effects of sulpiride are due to its prolactin-releasing and antigonadotropic effects and the hyperprolactinemia–amenorrhea state that it induces.[42][43]

References[]

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External links[]

  • Media related to Sulpiride at Wikimedia Commons
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