The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.[5]
Interactions[]
ZNF10 has been shown to interact with TRIM28.[6][7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID7865130.
^Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID8262519. S2CID19201834.
Lorenz P, Koczan D, Thiesen HJ (Apr 2001). "Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation". Biological Chemistry. 382 (4): 637–44. doi:10.1515/BC.2001.075. PMID11405226. S2CID13200652.
External links[]
ZNF10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.