CD24

CD24
Identifiers
Aliases	CD24, CD24A, CD24 molecule
External IDs	OMIM: 600074 GeneCards: CD24
showGene location (Human)
Chr.	Chromosome 6 (human)
End	106,975,627 bp
showGene ontology
Molecular function	• protein tyrosine kinase activator activity; • signal transducer activity; • GO:0001948 protein binding; • protein kinase binding;
Cellular component	• membrane; • plasma membrane; • cell surface; • anchored component of external side of plasma membrane; • membrane raft; • anchored component of membrane; • intracellular anatomical structure;
Biological process	• response to hypoxia; • regulation of MAPK cascade; • positive regulation of MAP kinase activity; • regulation of cytokine-mediated signaling pathway; • positive regulation of cytosolic calcium ion concentration; • chemokine receptor transport out of membrane raft; • T cell costimulation; • regulation of phosphorylation; • Wnt signaling pathway; • negative regulation of transforming growth factor beta3 production; • cell activation; • immune response-regulating cell surface receptor signaling pathway; • response to estrogen; • respiratory burst; • intrinsic apoptotic signaling pathway; • glomerular parietal epithelial cell differentiation; • cell adhesion; • glomerular visceral epithelial cell differentiation; • cholesterol homeostasis; • regulation of epithelial cell differentiation; • response to molecule of bacterial origin; • cell migration; • B cell receptor transport into membrane raft; • positive regulation of nephron tubule epithelial cell differentiation; • positive regulation of activated T cell proliferation; • positive regulation of protein tyrosine kinase activity; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	100133941
	n/a
	ENSG00000272398
	n/a
	P25063
	n/a
	NM_001291737; NM_001291738; NM_001291739; NM_013230; NM_001359084
	n/a
	NP_001278666; NP_001278667; NP_001278668; NP_037362; NP_001346013
	n/a
	Wikidata
View/Edit Human

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[3] CD24 is a cell adhesion molecule.

Function[]

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils^[4] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.^[5] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,^[6] and this appears to be defective in sepsis.^[6] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.^{[citation needed]}

References[]

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000272398 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.
^ Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. S2CID 39674808.
^ Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. S2CID 3492300.
^ Jump up to: ^a ^b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. S2CID 45838206.

Further reading[]

Li D, Zheng L, Jin L, Zhou Y, Li H, Fu J, Shi M, Du P, Wang L, Wu H, Chen GY, Zheng P, Liu Y, Wang FS, Wang S (September 2009). "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection". Hepatology. 50 (3): 735–42. doi:10.1002/hep.23047. PMID 19610054. S2CID 34010521.
Piotrowski P, Lianeri M, Wudarski M, Łacki JK, Jagodziński PP (June 2010). "CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus". Tissue Antigens. 75 (6): 696–700. doi:10.1111/j.1399-0039.2010.01447.x. PMID 20230526.
Honeth G, Bendahl PO, Ringnér M, Saal LH, Gruvberger-Saal SK, Lövgren K, Grabau D, Fernö M, Borg A, Hegardt C (2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503. PMID 18559090.
Nagy B, Szendroi A, Romics I (June 2009). "Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy". Pathology Oncology Research. 15 (2): 279–83. doi:10.1007/s12253-008-9077-1. PMID 18752058. S2CID 22572165.
Kim KH, Choi JS, Kim JM, Choi YL, Shin YK, Lee HC, Seong IO, Kim BK, Chae SW, Kim SH (March 2009). "Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium". Histology and Histopathology. 24 (3): 309–16. doi:10.14670/HH-24.309. PMID 19130400.
Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C (October 2009). "Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer". Neoplasia. 11 (10): 987–1002. doi:10.1593/neo.09670. PMC 2745665. PMID 19794958.
Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O (December 2009). "CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells". Stem Cells. 27 (12): 2928–40. doi:10.1002/stem.211. PMC 3322476. PMID 19725119.
Liu Y, Chen GY, Zheng P (December 2009). "CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns". Trends in Immunology. 30 (12): 557–61. doi:10.1016/j.it.2009.09.006. PMC 2788100. PMID 19786366.
Vesuna F, Lisok A, Kimble B, Raman V (December 2009). "Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression". Neoplasia. 11 (12): 1318–28. doi:10.1593/neo.91084. PMC 2794513. PMID 20019840.
Sagiv E, Arber N (February 2008). "The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy". Expert Review of Gastroenterology & Hepatology. 2 (1): 125–33. doi:10.1586/17474124.2.1.125. PMID 19072375. S2CID 22336532.
Bauerschmitz GJ, Ranki T, Kangasniemi L, Ribacka C, Eriksson M, Porten M, Herrmann I, Ristimäki A, Virkkunen P, Tarkkanen M, Hakkarainen T, Kanerva A, Rein D, Pesonen S, Hemminki A (July 2008). "Tissue-specific promoters active in CD44+CD24-/low breast cancer cells". Cancer Research. 68 (14): 5533–9. doi:10.1158/0008-5472.CAN-07-5288. PMID 18632604.
Carl JW, Liu JQ, Joshi PS, El-Omrani HY, Yin L, Zheng X, Whitacre CC, Liu Y, Bai XF (July 2008). "Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway". Journal of Immunology. 181 (1): 320–8. doi:10.4049/jimmunol.181.1.320. PMID 18566397. S2CID 10530971.
Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM (February 2009). "Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater". Modern Pathology. 22 (2): 306–13. doi:10.1038/modpathol.2008.192. PMID 19043399. S2CID 36610531.
Wang W, Wang X, Peng L, Deng Q, Liang Y, Qing H, Jiang B (January 2010). "CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation". Cancer Science. 101 (1): 112–9. doi:10.1111/j.1349-7006.2009.01370.x. PMID 19860845. S2CID 205235492.
Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, Saito K, Sohda M, Nakajima M, Nakajima T, Kuwano H (February 2009). "CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma". Annals of Surgical Oncology. 16 (2): 506–14. doi:10.1245/s10434-008-0252-0. PMID 19050962. S2CID 30259987.
Yang XR, Xu Y, Yu B, Zhou J, Li JC, Qiu SJ, Shi YH, Wang XY, Dai Z, Shi GM, Wu B, Wu LM, Yang GH, Zhang BH, Qin WX, Fan J (September 2009). "CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery". Clinical Cancer Research. 15 (17): 5518–27. doi:10.1158/1078-0432.CCR-09-0151. PMID 19706825. S2CID 15611706.
Lee JH, Kim SH, Lee ES, Kim YS (November 2009). "CD24 overexpression in cancer development and progression: a meta-analysis". Oncology Reports. 22 (5): 1149–56. doi:10.3892/or_00000548. PMID 19787233.
Gekara NO, Weiss S (November 2004). "Lipid rafts clustering and signalling by listeriolysin O". Biochemical Society Transactions. 32 (Pt 5): 712–4. doi:10.1042/BST0320712. PMID 15493995.
Athanassiadou P, Grapsa D, Gonidi M, Athanassiadou AM, Tsipis A, Patsouris E (2009). "CD24 expression has a prognostic impact in breast carcinoma". Pathology, Research and Practice. 205 (8): 524–33. doi:10.1016/j.prp.2009.01.008. PMID 19243896.
Ronaghi M, Vallian S, Etemadifar M (December 2009). "CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population". Psychiatry Research. 170 (2–3): 271–2. doi:10.1016/j.psychres.2009.01.002. PMID 19896210. S2CID 35984512.
van de Peppel J, Schaaf G, Matos A, Guo Y, Strini T, Verschoor W, Dudakovic A, van Wijnen A, van Leeuwen J (March 2021). "Cell Surface Glycoprotein CD24 Marks Bone Marrow-Derived Human Mesenchymal Stem/Stromal Cells with Reduced Proliferative and Differentiation Capacity In Vitro". Stem Cells & Development: 325–336. doi:10.1089/scd.2021.0027. PMID 33593128.

External links[]

CD24+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart
www.copewithcytokines.de: description of CD24 expression
CD24 human gene location in the UCSC Genome Browser.
CD24 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000272398 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959762-3] Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.

[4] Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. S2CID 39674808.

[5] Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. S2CID 3492300.

[Parlato_2014-6] Jump up to: ^a ^b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. S2CID 45838206.

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show v t Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350