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Ciclafrine ATC code
3-(1-Oxa-4-azaspiro[4.6]undec-2-yl)phenol
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 15 H 21 N O 2 Molar mass 247.338 g·mol−1 3D model (JSmol )
c1cc(cc(c1)O)C2CNC3(O2)CCCCCC3
InChI=1S/C15H21NO2/c17-13-7-5-6-12(10-13)14-11-16-15(18-14)8-3-1-2-4-9-15/h5-7,10,14,16-17H,1-4,8-9,11H2
Key:AJNAKEPPGKJNKU-UHFFFAOYSA-N
Ciclafrine (INN ) is a sympathomimetic phenethylamine and antihypertensive that was never marketed.[1] [2]
Synthesis [ ]
Ciclafrine can be prepared by the reaction of norfenefrine with cycloheptanone .[3]
References [ ]
^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents . CRC Press. pp. 586–. ISBN 978-0-412-46630-4 .
^ Korolkovas A (1988). Essentials of medicinal chemistry . John Wiley & Sons, Incorporated. p. 405. ISBN 978-0-471-88356-2 .
^ DE 2336746 , Satzinger, Gerhard & Herrmann, Manfred, "2-Hydroxyphenyl-1-oxa-4-azaspiro-alkan-Derivate [2-Hydroxyphenyl-1-oxa-4-azaspiro-alkane derivatives]", published 1975-02-13, assigned to Gödecke AG
Sympatholytic (and closely related) antihypertensives (C02 )
Sympatholytics (antagonize α-adrenergic vasoconstriction )
Central
α2 -Adrenergic receptor agonists
Clonidine
Guanabenz
Guanfacine
Guanoxabenz
Methyldopa #
Tiamenidine ‡
Adrenergic release inhibitors Imidazoline receptor agonists
Moxonidine
Rilmenidine
Tolonidine
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Peripheral
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Methoserpidine
Reserpine
Syrosingopine
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Direct
α1 -Adrenergic receptor blockers Non-selective α-adrenergic receptor blockers
Other antagonists
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
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BRL-44408
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β
See also: Receptor/signaling modulators
Dopaminergics
Serotonergics
Monoamine reuptake inhibitors
Monoamine releasing agents
Monoamine metabolism modulators
Monoamine neurotoxins
Categories :
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