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MK-9470
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Names
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Preferred IUPAC name
N-[(2S,3S)-3-(3-Cyanophenyl)-4-(4-ethoxyphenyl)butan-2-yl]-2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide
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Identifiers
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CAS Number
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- 945850-36-2 Y
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3D model (JSmol)
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ChemSpider
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UNII
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InChI=1S/C29H33N3O3/c1-6-34-25-13-11-22(12-14-25)17-26(24-9-7-8-23(16-24)18-30)21(3)32-28(33)29(4,5)35-27-15-10-20(2)19-31-27/h7-16,19,21,26H,6,17H2,1-5H3,(H,32,33)/t21-,26+/m0/s1 NKey: JWBGLSNXGRDLKH-HFZDXXHNSA-N NInChI=1/C29H33N3O3/c1-6-34-25-13-11-22(12-14-25)17-26(24-9-7-8-23(16-24)18-30)21(3)32-28(33)29(4,5)35-27-15-10-20(2)19-31-27/h7-16,19,21,26H,6,17H2,1-5H3,(H,32,33)/t21-,26+/m0/s1 Key: JWBGLSNXGRDLKH-HFZDXXHNBD
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CCOc1ccc(C[C@H]([C@H](C)NC(=O)C(C)(C)Oc2ccc(C)cn2)c3cccc(c3)C#N)cc1
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Properties
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Chemical formula
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C29H33N3O3
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Molar mass
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471.59 g/mol
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N (what is YN ?)
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Infobox references
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Chemical compound
MK-9470 is a synthetic compound, which binds to the CB1 cannabinoid receptor and functions as an inverse agonist.[1]
References[]
- ^ Burns, HD; Van Laere, K; Sanabria-Bohórquez, S; Hamill, TG; Bormans, G; Eng, WS; Gibson, R; Ryan, C; Connolly, B; Patel, S; Krause, S; Vanko, A; Van Hecken, A; Dupont, P; De Lepeleire, I; Rothenberg, P; Stoch, SA; Cote, J; Hagmann, WK; Jewell, JP; Lin, LS; Liu, P; Goulet, MT; Gottesdiener, K; Wagner, JA; de Hoon, J; Mortelmans, L; Fong, TM; Hargreaves, RJ (5 June 2007). "[18F] MK-9470, a Positron Emission Tomography (PET) Tracer for in vivo Human PET Brain Imaging of the Cannabinoid-1 Receptor". Proceedings of the National Academy of Sciences of the United States of America. 104 (23): 9800–5. Bibcode:2007PNAS..104.9800B. doi:10.1073/pnas.0703472104. PMC 1877985. PMID 17535893.
Cannabinoids |
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Phytocannabinoids | Cannabichromenes | |
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Cannabicyclols | |
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Cannabidiols | |
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Cannabielsoins | |
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Cannabigerols | |
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Cannabinols and cannabinodiols | |
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Cannabitriols | |
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Delta-8-tetrahydrocannabinols | |
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Delta-9-tetrahydrocannabinols |
- Delta-9-THC (THC)
- THCH
- THCP
- THCV
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Miscellaneous cannabinoids | |
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Active metabolites | |
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Endocannabinoids |
- Arachidonoyl ethanolamide (AEA; anandamide)
- 2-Arachidonoylglycerol (2-AG)
- 2-Arachidonyl glyceryl ether (2-AGE; noladin ether)
- 2-Oleoylglycerol (2-OG)
- N-Arachidonoyl dopamine (NADA)
- N-Arachidonylglycine (NAGly)
- N-Arachidonoyl serotonin (AA-5-HT)
- Docosatetraenoylethanolamide (DEA)
- Lysophosphatidylinositol (LPI)
- Oleamide
- Oleoylethanolamide (OEA)
- Palmitoylethanolamide (PEA)
- RVD-Hpα
- Stearoylethanolamide (SEA)
- O-Arachidonoyl ethanolamine (O-AEA; virodhamine)
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Synthetic cannabinoids | Classical cannabinoids (dibenzopyrans) | |
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Non-classical cannabinoids | |
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Adamantoylindoles | |
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Benzimidazoles | |
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Benzoylindoles | |
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Cyclohexylphenols | |
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Eicosanoids | |
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Hydrocarbons | |
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Indazole carboxamides | |
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Indazole-3- carboxamides | |
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Indole-3-carboxamides | |
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Indole-3-carboxylates | |
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Naphthoylindazoles | |
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Naphthoylindoles | |
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Naphthoylpyrroles | |
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Naphthylmethylindenes |
- AM-2201
- AM-694
- WIN-55,212-2
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Naphthylmethylindoles | |
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Phenylacetylindoles | |
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Pyrazolecarboxamides | |
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Pyrrolobenzoxazines | |
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Quinolinyl esters | |
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Tetramethylcyclo- propanoylindazoles | |
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Tetramethylcyclo- propanoylindoles |
- A-796,260
- A-834,735
- FUB-144
- UR-144
- XLR-11
- XLR-12
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Tetramethylcyclo- propylindoles | |
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Others | |
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Allosteric CBR ligands | |
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Endocannabinoid enhancers (inactivation inhibitors) | |
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Anticannabinoids (antagonists/inverse agonists/antibodies) | |
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- See also: Cannabinoid receptor modulators (cannabinoids by pharmacology)
- List of: AM cannabinoids
- JWH cannabinoids
- Designer drugs § Synthetic cannabimimetics
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Categories:
- Cannabinoids
- CB1 receptor antagonists
- Nitriles
- Phenol ethers
- Pyridines
- Cannabinoid stubs
Hidden categories:
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