Ipratropium bromide/salbutamol

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Ipratropium bromide/salbutamol
Combination of
Ipratropium bromideMuscarinic antagonist
SalbutamolShort-acting β2-adrenergic agonist
Clinical data
Trade namesCombivent, DuoNeb, Breva, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601063
License data
Routes of
administration		Inhalation
ATC code
Legal status
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • US: ℞-only
Identifiers
CAS Number
  • 1031840-23-9
  

Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][2][3] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1] It is taken by inhalation.[4]

Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[5] Each medication typically decreases bronchospasm and does so via different mechanisms.[1]

The combination was approved for medical use in the United States in 1996.[4] It is available as a generic medication.[2] In 2019, it was the 151st most commonly prescribed medication in the United States, with more than 4 million prescriptions.[6][7]

Society and culture[]

Since Combivent contains a chlorofluorocarbon-based propellant, it is being phased out in European Union countries. Chloroflourocarbons (CFC) are attributed to depletion of the ozone layer.

References[]

  1. ^ a b c d e "DailyMed - ipratropium bromide and albuterol sulfate inhalant". dailymed.nlm.nih.gov. Retrieved 18 April 2019.
  2. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
  3. ^ Gordon J, Panos RJ (March 2010). "Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease". Expert Opinion on Drug Metabolism & Toxicology. 6 (3): 381–92. doi:10.1517/17425251003649549. PMID 20163324. S2CID 31806856.
  4. ^ a b "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  5. ^ "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  6. ^ "The Top 300 of 2019". ClinCalc. Retrieved 16 October 2021.
  7. ^ "Albuterol; Ipratropium - Drug Usage Statistics". ClinCalc. Retrieved 16 October 2021.

External links[]

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