List of progestogens

Progesterone.

Steroid ring system.

This is a list of progestogens that are or that have been used in clinical or veterinary medicine. They are steroids and include derivatives of progesterone and testosterone.

Progesterone derivatives[]

Compound	Chemical name	Structure
Progesterone	Pregn-4-ene-3,20-dione
Quingestrone	Progesterone 3-cyclopentyl enol ether

Retroprogesterone derivatives[]

Compound	Chemical name	Structure
Retroprogesterone	9β,10α-Progesterone
Dydrogesterone	6-Dehydro-9β,10α-progesterone
Trengestone	6-Chloro-1,6-didehydro-9β,10α-progesterone

Note that although an active progestogen, retroprogesterone is not medically used.

17α-Hydroxyprogesterone derivatives[]

Compound	Chemical name	Structure
Hydroxyprogesterone	17α-Hydroxyprogesterone
Acetomepregenol (mepregenol diacetate)	3β,17α-Diacetoxy-6-methyl-6-dehydro-3-deketoprogesterone
Algestone	16α,17α-Dihydroxyprogesterone
Algestone acetophenide	16α,17α-Dihydroxyprogesterone acetophenide
Anagestone acetate	17α-Acetoxy-6α-methyl-3-deketoprogesterone
Chlormadinone acetate	17α-Acetoxy-6-chloro-6-dehydroprogesterone
Chlormethenmadinone acetate	17α-Acetoxy-6-chloro-16-methylene-6-dehydroprogesterone
Cyproterone acetate	17α-Acetoxy-1,2α-methylene-6-chloro-6-dehydroprogesterone
Delmadinone acetate	17α-Acetoxy-6-chloro-1,6-didehydro-progesterone
Flugestone acetate (flurogestone acetate)	17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone
Flumedroxone acetate	17α-Acetoxy-6α-(trifluoromethyl)progesterone
Hydroxyprogesterone acetate	17α-Acetoxyprogesterone
Hydroxyprogesterone caproate	17α-Hexanoxyprogesterone
Hydroxyprogesterone heptanoate	17α-Heptanoxyprogesterone
Medroxyprogesterone acetate	17α-Acetoxy-6α-methylprogesterone
Megestrol acetate	17α-Acetoxy-6-methyl-6-dehydroprogesterone
Melengestrol acetate	17α-Acetoxy-16-methylene-6-methyl-6-dehydroprogesterone
Methenmadinone acetate	17α-Acetoxy-16-methylene-6-dehydroprogesterone
Osaterone acetate	17α-Acetoxy-6-chloro-2-oxa-6-dehydroprogesterone
Pentagestrone acetate	17α-Acetoxyprogesterone 3-cyclopentyl enol ether

Note that 17α-hydroxyprogesterone is inactive as a progestogen and is not used medically.

The 19-norprogesterone derivatives gestonorone caproate (gestronol hexanoate), nomegestrol acetate, segesterone acetate (nestorone, elcometrine), and norgestomet are also derivatives of 17α-hydroxyprogesterone (see below).

17α-Methylprogesterone derivatives[]

Compound	Chemical name	Structure
17α-Methylprogesterone	17α-Methylprogesterone
Medrogestone	6,17α-Dimethyl-6-dehydroprogesterone

Note that although an active progestogen, 17α-methylprogesterone is not medically used.

The 19-norprogesterone derivatives demegestone, promegestone, and trimegestone are also derivatives of 17α-methylprogesterone (see below).

Other 17α-substituted progesterone derivatives[]

Compound	Chemical name	Structure
Haloprogesterone	6α-Fluoro-17α-bromoprogesterone
Proligestone	14α,17α-Propylidenedioxyprogesterone

19-Norprogesterone derivatives[]

Compound	Chemical name	Structure
19-Norprogesterone	19-Norprogesterone
Demegestone	17α-Methyl-9-dehydro-19-norprogesterone
Gestonorone caproate (gestronol hexanoate)	17α-Caproxy-19-norprogesterone
Nomegestrol acetate	17α-Acetoxy-6-methyl-6-dehydro-19-norprogesterone
Norgestomet	17α-Acetoxy-11β-methyl-19-norprogesterone
Promegestone	17α,21-Dimethyl-9-dehydro-19-norprogesterone
Segesterone acetate (nestorone, elcometrine)	17α-Acetoxy-16-methylene-19-norprogesterone
Trimegestone	21β-Hydroxy-17α,21-dimethyl-9-dehydro-19-norprogesterone

Note that although an active progestogen, 19-norprogesterone is not medically used.

Testosterone derivatives[]

Compound	Chemical name(s)	Structure
Testosterone	17β-Deacetyl-17β-hydroxyprogesterone Androst-4-en-17β-ol-3-one

Note that testosterone itself does not have significant progestogenic activity. Testosterone is instead classified as an anabolic-androgenic steroid and is included here purely because it is the parent structure of this group of progestins.

17α-Ethynyltestosterone derivatives[]

Compound	Chemical name(s)	Structure
Ethisterone (ethinyltestosterone)	17α-Ethynyltestosterone
Danazol (2,3-isoxazolethisterone)	2,3-Isoxazol-17α-ethynyltestosterone^?
Dimethisterone	6α,21-Dimethyl-17α-ethynyltestosterone

19-Nortestosterone derivatives[]

Compound	Chemical name(s)	Structure
Nandrolone (nortestosterone)	19-Nortestosterone
Oxendolone (TSAA-291)	16β-Ethyl-19-nortestosterone

Note that while nandrolone (19-nortestosterone) does have significant progestogenic activity, it is not used as a progestogen. It is instead classified as an androgenic-anabolic steroid and is included here purely because it is an important parent structure of this group of progestins.

17α-Ethynyl-19-nortestosterone derivatives[]

Estranes[]

Compound	Chemical name(s)	Structure
Norethisterone (norethindrone)	17α-Ethynyl-19-nortestosterone
Etynodiol diacetate (ethynodiol diacetate)	17α-Ethynyl-3-deketo-3β-hydroxy-19-nortestosterone 3β,17β-diacetate
Lynestrenol (3-deketonorethisterone)	17α-Ethynyl-3-deketo-19-nortestosterone
Norethisterone acetate (norethindrone acetate)	17α-Ethynyl-19-nortestosterone 17β-acetate
Norethisterone enanthate (norethindrone enanthate)	17α-Ethynyl-19-nortestosterone 17β-enanthate
Noretynodrel (norethynodrel)	17α-Ethynyl-δ⁵⁽¹⁰⁾-19-nortestosterone
Norgestrienone (ethinyltrenbolone)	17α-Ethynyl-19-nor-δ^9,11-testosterone
Quingestanol acetate	4-Hydro-17α-ethynyl-19-nor-δ^3,5-testosterone 3-cyclopentyl ether 17β-acetate^?
Tibolone (7α-methylnoretynodrel)	7α-Methyl-17α-ethynyl-19-nor-δ⁵⁽¹⁰⁾-testosterone

18-Methylestranes (13β-ethylgonanes)[]

Compound	Chemical name(s)	Structure
Desogestrel	3-Deketo-11-methylene-17α-ethynyl-18-methyl-19-nortestosterone
Etonogestrel (3-ketodesogestrel)	11-Methylene-17α-ethynyl-18-methyl-19-nortestosterone
Gestodene (15-dehydronorgestrel)	17α-Ethynyl-18-methyl-19-nor-δ¹⁵-testosterone
Gestrinone (ethylnorgestrienone, R-2323)	17α-Ethynyl-18-methyl-19-nor-δ^9,11-testosterone
Levonorgestrel	17α-Ethynyl-18-methyl-19-nortestosterone
Norelgestromin (17β-deacetylnorgestimate, norgestrel 3-oxime)	17α-Ethynyl-18-methyl-19-nortestosterone 3-oxime
Norgestimate	17α-Ethynyl-18-methyl-19-nortestosterone 3-oxime 17β-acetate
Norgestrel (13-methylnorethisterone)	rac-13-Ethyl-17α-ethynyl-19-nortestosterone

Other 17α-substituted 19-nortestosterone derivatives[]

Compound	Chemical name(s)	Structure
Allylestrenol (allyloestrenol)	3-Deketo-17α-allyl-19-nortestosterone
Altrenogest (allyltrenbolone, allyltrienolone)	17α-Allyl-19-nor-δ^9,11-testosterone
Dienogest	17α-Cyanomethyl-19-nor-δ⁹-testosterone
Normethandrone (methylestrenolone, normethandrolone, normethisterone, methylnortestosterone)	17α-Methyl-19-nortestosterone
Norvinisterone (vinylnortestosterone, SC-4641)	17α-Vinyl-19-nortestosterone
Norgesterone (norvinodrel, vinylestrenolone, vinylnoretynodrel)	17α-Vinyl-δ⁵⁽¹⁰⁾-19-nortestosterone