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Otenabant ATC code
1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4- carboxamide
CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) Formula C 25 H 25 Cl 2 N 7 O Molar mass 510.42 g·mol−1 3D model (JSmol )
CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N
InChI=1S/C25H25Cl2N7O/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35)
N Key:UNAZAADNBYXMIV-UHFFFAOYSA-N
N
N Y (what is this?)
Otenabant (CP-945,598 ) is a drug which acts as a potent and highly selective CB1 antagonist .[1] It was developed by Pfizer for the treatment of obesity ,[2] but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant .[3]
See also [ ]
Cannabinoid receptor antagonist
References [ ]
Antiobesity agents /Anorectics (A08 )
Central
Stimulants
4-Methylamphetamine ‡
Amfecloral
Amfepentorex
Amfepramone
Aminorex ‡
Amphetamine
Amphetaminil
Atomoxetine
Benfluorex ‡
Benzphetamine
Bupropion (+naltrexone ; +zonisamide† )
Cathine
Cathinone
Chlorphentermine
Ciclazindol
Clobenzorex
Cloforex
Clominorex
Clortermine
Dexfenfluramine ‡
Dextroamphetamine
Dexmethylphenidate
Difemetorex ‡
Dimethylcathinone
Ephedrine
Ephedra ‡
Etilamfetamine
Etolorex
Fenbutrazate
Fencamfamin
Fenethylline
Fenfluramine (+phentermine ‡ )
Fenproporex
Fludorex
Fluminorex
Furfenorex ‡
Indanorex
Khat
Levopropylhexedrine
Lisdexamfetamine
Manifaxine
Mazindol
Mefenorex
Methamphetamine
Methylphenidate
Norfenfluramine
Pemoline
Pentorex
Phendimetrazine
Phenethylamine
Phenmetrazine
Phentermine (+topiramate )
Phenylpropanolamine
Picilorex
Pipradrol
Prolintane
Propylhexedrine
Pseudoephedrine
Pyrovalerone
Radafaxine
Reboxetine
Setazindol
Sibutramine ‡
Synephrine
Tesofensine
Viloxazine
Xylopropamine
Zylofuramine
Cannabinoid receptor antagonists Others
5-HTP
Beloranib §
Galactomannan
Glucomannan
L-DOPA
L-Phenylalanine
L-Tryptophan
L-Tyrosine
Lorcaserin
Lu AA-33810
Metformin
Naltrexone
Naloxone
Oxyntomodulin
P57
Peptide YY
Setmelanotide
Topiramate
Velneperit §
Yohimbine (Yohimbe )
Zonisamide
Water
Peripheral
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
Cannabinoids
Phytocannabinoids
Cannabichromenes Cannabicyclols Cannabidiols Cannabielsoins Cannabigerols Cannabinols and cannabinodiols Cannabitriols Delta-8-tetrahydrocannabinols Delta-9-tetrahydrocannabinols
Delta-9-THC (THC)
THCH
THCP
THCV
Miscellaneous cannabinoids Active metabolites
Endocannabinoids
Arachidonoyl ethanolamide (AEA; anandamide)
2-Arachidonoylglycerol (2-AG)
2-Arachidonyl glyceryl ether (2-AGE; noladin ether)
2-Oleoylglycerol (2-OG)
N-Arachidonoyl dopamine (NADA)
N-Arachidonylglycine (NAGly)
N-Arachidonoyl serotonin (AA-5-HT)
Docosatetraenoylethanolamide (DEA)
Lysophosphatidylinositol (LPI)
Oleamide
Oleoylethanolamide (OEA)
Palmitoylethanolamide (PEA)
RVD-Hpα
Stearoylethanolamide (SEA)
O-Arachidonoyl ethanolamine (O-AEA; virodhamine)
Synthetic cannabinoid receptors agonists / neocannabinoidss
Classical cannabinoids (dibenzopyrans) Non-classical cannabinoids Adamantoylindoles Benzimidazoles Benzoylindoles
AM-630
AM-679
AM-694
AM-1241
AM-2233
GW-405,833 (L-768,242)
Pravadoline
RCS-4
WIN 54,461
Cyclohexylphenols Eicosanoids Hydrocarbons Indazole carboxamides Indazole-3- carboxamides Indole-3-carboxamides Indole-3-carboxylates Naphthoylindazoles Naphthoylindoles Naphthoylpyrroles Naphthylmethylindenes Naphthylmethylindoles Phenylacetylindoles Pyrazolecarboxamides Pyrrolobenzoxazines Quinolinyl esters Tetramethylcyclo- propanoylindazoles Tetramethylcyclo- propanoylindoles
A-796,260
A-834,735
FUB-144
UR-144
XLR-11
XLR-12
Tetramethylcyclo- propylindoles Others
Allosteric CBR ligands Endocannabinoid enhancers (inactivation inhibitors) Anticannabinoids (antagonists/inverse agonists/antibodies)
See also: Cannabinoid receptor modulators (cannabinoids by pharmacology)
List of: AM cannabinoids
JWH cannabinoids
Designer drugs § Synthetic cannabimimetics
Receptor (ligands )
CB1
Agonists (abridged; see here for more) : 2-AG
2-AGE (noladin ether)
11-Hydroxy-THC
α-Amyrin · β-Amyrin
AB-CHMINACA
AM-1220
AM-1221
AM-1235
AM-2201
AM-2232
Anandamide
AZ-11713908
Cannabinol
CB-13
CP 47,497
CP 55,940
Dimethylheptylpyran
DEA
ECG
EGCG
Epicatechin
Gallocatechol (gallocatechin)
Honokiol
HU-210
JWH-007
JWH-015
JWH-018
JWH-073
Kavain
L-759,633
Levonantradol
Menabitan
Nabilone
Nabitan
NADA
O-1812
Oleamide
Pravadoline
Serinolamide A
THC (dronabinol)
UR-144
WIN 55,212-2
Yangonin
CB2
Agonists: 2-AG
2-AGE (noladin ether)
3,3'-Diindolylmethane
4-O-Methylhonokiol
α-Amyrin · β-Amyrin
A-796,260
A-834,735
A-836,339
AM-1221
AM-1235
AM-1241
AM-2232
Anandamide
AZ-11713908
Cannabinol
Caryophyllene
CB-13
CBS-0550
CP 55,940
GW-405,833 (L-768,242)
GW-842,166X
HU-308
JTE 7-31
JWH-007
JWH-015
JWH-018
JWH-133
L-759,633
L-759,656
Magnolol
MDA-19
Nabitan
NADA
Olorinab (APD-371)
PF-03550096
S-444,823
SER-601
Serinolamide A
UR-144
Tedalinab
THC (dronabinol)
THCV
Virodhamine
NAGly (GPR18 )
Agonists: Abnormal cannabidiol
ACPA
AM251
Anandamide
Cannabidiol
NADGly
THC (dronabinol)
O-1602
GPR55
Agonists: 2-AGE (noladin ether)
Abnormal cannabidiol
AM-251
CP 55,940
Lysophosphatidylinositol
O-1602
Oleoylethanolamide
Palmitoylethanolamide
THC (dronabinol)
GPR119 Unsorted
Transporter (modulators )
eCBTs
Inhibitors:
AM-404
Arachidonoyl serotonin
Cannabidiol
Guineensine
LY-2183240
Paracetamol (acetaminophen)
URB-597
VDM-11
Enzyme (modulators )
FAAH MAGL
Inhibitors:
IDFP
JZL-184
JZL-195
MAFP
URB-602
ABHD6 ABHD12
Inhibitors: Betulinic acid
Maslinic acid
MAFP
Oleanolic acid
Orlistat (tetrahydrolipstatin)
Ursolic acid
Others
Precursors: Phosphatidylethanolamine
NAPE
Diacylglycerol
Others: (directly potentiates activity of 2-AG at CB1 receptor)
(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
Categories :
Drugs not assigned an ATC code Cannabinoids Purines Piperidines Carboxamides Chloroarenes Pfizer brands CB1 receptor antagonists Cannabinoid stubs Hidden categories:
CS1: long volume value Articles with changed ChemSpider identifier Articles with changed EBI identifier Articles with changed InChI identifier Chemical pages without DrugBank identifier Drugs with no legal status Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields All stub articles