Metfendrazine

Metfendrazine
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 1-methyl-1-(1-methyl-2-phenyl-ethyl)hydrazine;
CAS Number	3734-26-7;
PubChem CID	19516;
ChemSpider	18390;
Chemical and physical data
Formula	C10H16N2
Molar mass	164.252 g·mol−1

Metfendrazine (HM-11, MO-482), also known as methphendrazine, is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class.^[1]^[2] It was investigated as an antidepressant, but was never marketed.

References[]

^ Miquel, J.; Mijan, C. D. (1962). "Metfendrazine, a new inhibitor of monoamine oxidase". Arch. Inst. Farmacol. Exp. (Madrid). 14: 47–59.
^ Kothari NJ, Saunders JC, Kline NS, Griffen JA (October 1960). "A comparison of perphenazine, proketazine, nialamide and MO-482 in chronic schizophrenics". The American Journal of Psychiatry. 117 (4): 358–60. doi:10.1176/ajp.117.4.358. PMID 13753478.

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[Metfendrazine,_a_new_inhibitor_of_monoamine_oxidase-1] Miquel, J.; Mijan, C. D. (1962). "Metfendrazine, a new inhibitor of monoamine oxidase". Arch. Inst. Farmacol. Exp. (Madrid). 14: 47–59.

[pmid13753478-2] Kothari NJ, Saunders JC, Kline NS, Griffen JA (October 1960). "A comparison of perphenazine, proketazine, nialamide and MO-482 in chronic schizophrenics". The American Journal of Psychiatry. 117 (4): 358–60. doi:10.1176/ajp.117.4.358. PMID 13753478.

[1]

[2]

v t Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carisoprodol Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 1-methyl-1-(1-methyl-2-phenyl-ethyl)hydrazine
CAS Number	3734-26-7
PubChem CID	19516
ChemSpider	18390
Chemical and physical data
Formula	C₁₀H₁₆N₂
Molar mass	164.252 g·mol⁻¹

Metfendrazine

See also[]

References[]