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Chemical compound
5-Fluoro-MET
N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
PubChem CID Formula C 13 H 17 F N 2 Molar mass 220.291 g·mol−1 3D model (JSmol )
CCN(C)CCC1=CNC2=C1C=C(C=C2)F
InChI=1S/C13H17FN2/c1-3-16(2)7-6-10-9-15-13-5-4-11(14)8-12(10)13/h4-5,8-9,15H,3,6-7H2,1-2H3
Key:XRWQULAXCLVBPP-UHFFFAOYSA-N
5-Fluoro-MET (5F-MET , 5-fluoro-N -methyl-N -ethyltryptamine ) is a psychedelic tryptamine derivative related to drugs such as 5-Fluoro-DMT and N-Methyl-N-ethyltryptamine (MET). It acts as an agonist at the 5-HT2A receptor with an EC50 of 20.6 nM and produces a head-twitch response in animal studies. Ring fluorination in this case increases efficacy at 5-HT2A , with 5F-MET having an efficacy of 87.6% vs 5-HT , vs 36.2% for the partial agonist MET. It is claimed to have antidepressant activity.[1]
See also [ ]
References [ ]
^ WO 2021/168082 , Kruegel AC, Sporn J, "Specific Tryptamines for use in the Treatment of Mood Disorders.", published 26 August 2021, assigned to Gilgamesh Pharmaceuticals, Inc..
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Categories :
Psychedelic tryptamines Tryptamines Fluoroarenes Pharmacology stubs Hidden categories:
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