DADLE
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IUPAC name
(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
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Other names
• [D-Ala2, D-Leu5]-Enkephalin
• L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH | |
Identifiers | |
CAS Number
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3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.059.337 |
PubChem CID
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UNII | |
InChI
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Properties | |
Chemical formula
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C29H39N5O7 |
Molar mass | 569.659 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
what is ?) | (|
Infobox references | |
DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective delta opioid receptor agonist, it also binds to the μ1 subtype of mu opioid receptors.
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.[1][2]
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.
See also[]
- DAMGO
- DPDPE
References[]
- ^ "Medical Dictionary Online". Archived from the original on 2007-08-28. Retrieved 2007-11-10.
- ^ Online Medical Dictionary, enkephalin, leucine-2-alanine[permanent dead link]
Categories:
- Synthetic opioids
- Opioid peptides
- Mu-opioid receptor agonists
- Delta-opioid receptor agonists
- Analgesic stubs