Meclofenoxate
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ECHA InfoCard | 100.000.107 |
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Formula | C12H16ClNO3 |
Molar mass | 257.71 g·mol−1 |
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Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement.[1][2][3][self-published source?] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).
In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests.[4] Meclofenoxate also increases cellular membrane phospholipids.[citation needed] It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.[3]
Side effects[]
Meclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.[3]
Research[]
Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.[5][6]
Brand names[]
In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[7]
See also[]
- Adafenoxate
- Cyprodenate
- ISRIB
References[]
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
- ^ Jump up to: a b c d Haavisto M (1 May 2008). Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia. Lulu.com. pp. 167–. ISBN 978-1-4092-0335-3.[self-published source]
- ^ Marcer D, Hopkins SM (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
- ^ Donaldson T (1 January 2003). "A Brief History of Anti-aging Drugs". In Klatz R, Goldman B (eds.). The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. pp. 66–. ISBN 978-0-9668937-3-1.
- ^ Hothschild R (August 1973). "Effect of dimethylamnioethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimential Gerontology. doi:10.1016/0531-5565(73)90024-7. PMID 4147092.
- ^ Zhou Y (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.
- Dimethylamino compounds
- Antidementia agents
- Carboxylate esters
- Chloroarenes
- Cholinergics
- Nootropics
- Phenol ethers