Oxymorphol
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Other names | 4,5α-Epoxy-17-methylmorphinan-3,6,14-triol |
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Pharmacokinetic data | |
Metabolism | hepatic |
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Chemical and physical data | |
Formula | C17H21NO4 |
Molar mass | 303.358 g·mol−1 |
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Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-Epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-Epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol).[1] . It is produced by the human body as an active metabolite of oxymorphone and some bacteria as an intermediate in turning morphine into hydromorphone.[2] It can also be manufactured and is the subject of patents by drug companies looking for new semi-synthetic analgesics and cough suppressants.
A derivative of oxymorphol, , was discovered in the first decade of this century and the subject of a patent application by Endo for an analgesic and antitussive.[3]
References[]
- ^ α-Oxymorphol as "Hydromorphinol"
- ^ Cone EJ, Darwin WD, Buchwald WF, Gorodetzky CW (1983). "Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 11 (5): 446–50. PMID 6194952.
- ^ http://www.faqs.org/patents/app/20090018154
Categories:
- Opioid metabolites
- Morphinans
- Semisynthetic opioids
- Mu-opioid receptor agonists