RTI-171
From Wikipedia, the free encyclopedia
Identifiers | |
---|---|
IUPAC name
| |
CAS Number | |
PubChem CID | |
ChemSpider |
|
Chemical and physical data | |
Formula | C19H24N2O |
Molar mass | 296.414 g·mol−1 |
3D model (JSmol) | |
SMILES
| |
InChI
| |
NY (what is this?) |
(–)-2β-(3-Methylisoxazol-5-yl)-3β-(p-tolyl)tropane (RTI-4229-171) is a phenyltropane derivative which acts as a selective dopamine reuptake inhibitor, with a relatively slow onset of action and short duration of effects found in animal studies.[1] However, other studies have shown it to have the most pronounced effects in terms of speed of onset and rate of stimulation among many differing phenyltropanes.[2]
See also[]
References[]
- ^ Kimmel HL, Carroll FI, Kuhar MJ (December 2001). "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence. 65 (1): 25–36. doi:10.1016/S0376-8716(01)00144-2. PMID 11714587.
- ^ Kimmel, Heather L.; O'Connor, Joann A.; Carroll, F. Ivy; Howell, Leonard L. (2007). "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology Biochemistry and Behavior. 86 (1): 45–54. doi:10.1016/j.pbb.2006.12.006. ISSN 0091-3057. PMC 1850383. PMID 17258302.
Phenyltropanes (classifications) | |
---|---|
2-Carboxymethyl Esters |
|
(3,4-Disubstituted Phenyl)-tropanes |
|
Arylcarboxy |
|
Carboxyalkyl |
|
Acyl | |
β,α Stereochemistry |
|
α,β Stereochemistry |
|
Heterocycles: 3-Substituted-isoxazol-5-yl |
|
Heterocycles: 3-Substituted-1,2,4-oxadiazole | |
N-alkyl |
|
N-replaced (S,O,C) |
|
Irreversible |
|
Nortropanes (N-demethylated) |
Stimulants | |
---|---|
Adamantanes |
|
Adenosine antagonists |
|
Alkylamines |
|
Ampakines | |
Arylcyclohexylamines |
|
Benzazepines |
|
Cathinones |
|
Cholinergics |
|
Convulsants |
|
Eugeroics |
|
Oxazolines |
|
Phenethylamines |
|
Phenylmorpholines |
|
Piperazines | |
Piperidines |
|
Pyrrolidines | |
Racetams |
|
Tropanes |
|
Tryptamines | |
Others |
|
ATC code: N06B |
Dopamine receptor modulators | |||||||
---|---|---|---|---|---|---|---|
D1-like |
| ||||||
D2-like |
| ||||||
|
This drug article relating to the nervous system is a stub. You can help Wikipedia by . |
- v
- t
Retrieved from ""
Categories:
- Tropanes
- RTI compounds
- Dopamine reuptake inhibitors
- Nervous system drug stubs
Hidden categories:
- Articles with changed ChemSpider identifier
- Articles with changed InChI identifier
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- All stub articles