Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazinederivative which acts as a D2 and D3 receptoragonist. It also has α2-adrenergic antagonist properties.[2][3]
Treatment of Parkinson's disease (PD), either as monotherapy (without levodopa)) or in combination with L-DOPA therapy, in the early stages of the disease as well as in the advanced ones
Treatment of pathologicalcognitive deficits in the elderly (impaired attention, motivation, memory, etc.)
Treatment of dizziness in the young patients
Treatment of retinalischemic manifestations
Adjunctive treatment of intermittent claudication due to peripheral vascular disease (PVD) of the lower limbs (stage 2)
Adjunctive treatment of anhedonia and treatment-resistant depression in unipolar and bipolar depressives (off label)
Treatment of gait disorders associated with Parkinson's disease (no related cause) and other forms of parkinsonism
Other uses[]
The drug has been shown to enhance working memory capacities in normal aging adults.[4]
In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.[5]
It enhances cognitive skill learning in healthy older adults.[6]
It showed a positive effect in restless legs syndrome.[7]
Dosage[]
Parkinson's disease[]
Administration of piribedil should be initiated with one sustained-release tablet (50 mg) daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:
As monotherapy: three to five tablets in three to five doses daily.
In combination with L-DOPA therapy: one to three tablets daily.
Other indications[]
One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.
Side effects[]
Minor gastrointestinal upset (nausea, vomiting, flatulence, etc.) in predisposed individuals, or when taken between meals: adjust dosage individually, and/or add domperidone;
Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness);
Mild dizziness, confusion and feeling "drunk" also may occur.
As with other dopamine agonists (like pramipexole and ropinirole), compulsive behavior like pathological gambling, overeating, excessive shopping, increased libido, sexual and/or other intense urges, may develop.[8][9]
Another rare side effect of piribedil is excessive daytime sleepiness and unintended sleep episodes.[9][10]
Overdose[]
At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone (CTZ). Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.
Interactions[]
Dopamine antagonists reduce the effect of piribedil.
Pharmacology[]
Pharmacodynamics[]
Dopamine receptoragonist, selective for subtypes D2 and D3.
Dopamine receptorantagonist, selective for subtypes D4.[11][12]
Adrenergic receptorantagonist, subtypes α2A and α2C: could be the reason why piribedil seems to cause less drowsiness than other dopamine agonists.[13]
Lack of affinity to serotonin receptor 5-HT2B: theoretically no risk of heart valve impairment.[13]
^Gierski, F.; Peretti, C.; Ergis, A. (30 January 2007). "Effects of the dopamine agonist piribedil on prefrontal temporal cortical network function in normal aging as assessed by verbal fluency". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31 (1): 262–268. doi:10.1016/j.pnpbp.2006.06.017. PMID16876301.
^Bochkarev, V. K.; Faĭzulloev, A. Z.; Avedisova, A. S. (2005). "Efficacy of pronoran in age-related memory impairment". Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova. 105 (2): 46–50. PMID15792142.
^Peretti, C. S.; Gierski, F.; Harrois, S. (November 2004). "Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil". Psychopharmacology. 176 (2): 176–182. doi:10.1007/s00213-004-1869-8. PMID15138753.
^Evidente, V. G. (May 2001). "Piribedil for restless legs syndrome: a pilot study". Movement Disorders. 16 (3): 579–581. doi:10.1002/mds.1104. PMID11391766.
^Tschopp L.; Salazar Z.; et al. (2010). "Impulse control disorder and piribedil: report of 5 cases". Clin. Neuropharmacology. 33 (1): 11–13. doi:10.1097/WNF.0b013e3181c4ae2e. PMID19959959.
^ Jump up to: abTRIVASTAL Retard 50 (piribedil) Prescribing Information, Servier Laboratories, April 2008. [1]
^Gouraud A.; Millaret A.; et al. (2011). "Piribedil-induced sleep attacks in patients without Parkinson disease: a case series". Clin. Neuropharmacology. 34 (3): 104–107. doi:10.1097/WNF.0b013e31821f0d8b. PMID21586915.
^Arnsten et al., 2000; Nagaraja and Jayashree, 2001. "Piribedil".CS1 maint: multiple names: authors list (link)
Salvinorin A Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).
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